STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
dsbDPutative thiol:disulphide interchange protein; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity); Belongs to the thioredoxin family. DsbD subfamily. (567 aa)    
Predicted Functional Partners:
Cj1380
Putative periplasmic protein; Original (2000) note: Cj1380, probable periplasmic protein, len: 236 aa; some similarity to e.g. DSBG_ECOLI thiol:disulfide interchange protein DSBG precursor (248 aa), fasta scores; opt: 138 z-score: 165.8 E(): 0.062,26.8% identity in 164 aa overlap (the active site is conserved). 34.1% identity to HP0231. Contains probable N-terminal signal sequence; Updated (2006) note: Paper identified linking protein to glycoprotein. Functional classification -Miscellaneous periplasmic proteins; PMID:12186869.
  
 
 0.972
Cj1106
Original (2000) note: Cj1106, possible periplasmic thioredoxin, len: 200 aa; similar to active site region of thioredoxins e.g. THIO_BACSU thioredoxin (103 aa), fasta scores; opt: 112 z-score: 150.6 E(): 0.43, 37.7% identity in 69 aa overlap. Contains probable N-terminal signal sequence. No Hp match. Also similar to Cj1207c (29.4% identity in 201 aa overlap); Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet,so putative kept in product function. Functional classification - Energy metabolism - Electron transport.
  
 
 0.957
mrsA
Putative peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
    
 
 0.903
Cj1112c
Putative SelR domain containing protein; Original (2000) note: Cj1112c, unknown, len: 119 aa; similar to hypothetical proteins e.g. YEAA_ECOLI (137 aa), fasta scores; opt: 329 z-score: 423.3 E(): 2.8e-16,44.8% identity in 116 aa overlap. Also some similarity to part of e.g. PMSR_STRPN peptide methionine sulfoxide reductase (312 aa), fasta scores; opt: 277 z-score: 353.8 E(): 2.1e-12, 42.0% identity in 119 aa overlap. No Hp match. No dedtectable siilarity to C.j. mrsA (Cj0637c); Updated (2006) note: Pfam domain PF01641 SelR domain identified within CDS. Product function modified to more [...]
    
 
 0.903
Cj1207c
Original (2000) note: Cj1207c, possible lipoprotein thiredoxin, len: 185 aa; some similarity to TR:G4100188 (EMBL:U95250) Treponema pallidum predicted thioredoxin (185 aa), fasta scores; opt: 196 z-score: 242.3 E(): 3.4e-06, 31.5% identity in 111 aa overlap, and HELX_RHOCA thiol:disulfide interchange protein(176 aa), fatsa scores; opt: 153 z-score: 192.6 E(): 0.002, 23.2% identity in 142 aa overlap. 23.7% identity to HP0762. Also similar to Cj1106 (29.4% identity in 201 aa overlap). Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane l [...]
  
 
 0.893
Cj1664
Original (2000) note: Cj1664, possible periplasmic thiredoxin, len: 162 aa; similar to e.g. TR:CAA21354 (EMBL:AL031866) Yersinia pestis ORF31 in 102 kbases unstable region (165 aa), fast scores; opt: 225 z-score: 278.4 E(): 3.5e-08, 33.3% identity in 141 aa overlap, and weakly to RESA_BACSU RESA protein (contains thiredoxin domain) (181 aa), fasta scores; opt: 124 z-score: 159.5 E(): 0.15, 25.0% identity in 112 aa overlap. No Hp match. Contains PS00194 Thioredoxin family active site and probable N-terminal signal sequence; Updated (2006) note: Specific characterisation with acceptable [...]
   
 
 0.864
Cj1665
Original (2000) note: Cj1665, possible lipoprotein thiredoxin, len: 167 aa; similar to TR:O33920 (EMBL:U75949) Salmonella typhimurium suppressor for copper-sensitivity D (168 aa), fasta scores; opt: 121 z-score: 163.1 E(): 0.093, 27.5% identity in 153 aa overlap, and weakly to many thiredoxins, e.g. THIO_BUCAP thioredoxin (108 aa), fasta scores; opt: 108 z-score: 149.9 E(): 0.5, 28.6% identity in 112 aa overlap. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site. No Hp match; Updated (2006) note: Spec [...]
   
 
 0.864
Cj0602c
MOSC-domain containing protein; Original (2000) note: Cj0602c, unknown, len: 222 aa; similar to hypothetical proteins e.g. YIIM_ECOLI (234 aa), fasta scores; opt: 298 z-score: 406.4 E(): 2.4e-15,30.4% identity in 207 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF03475 3-alpha domain and PF03473 MOSC domain were identified within CDS. Product modified to more specific family member due to motif match. Functional classification - Misc.
  
    0.800
dsbB
Putative disulphide oxidoreductase; Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity).
   
  
 0.752
Cj0604
Putative polyphosphate kinase; Original (2000) note: Cj0604, unknown, len: 293 aa; similar to hypothetical proteins e.g. TR:O05877 (EMBL:O05877) Mycobacterium tuberculosis Rv3232c (MTCY20B11.07c) (295 aa), fasta scores; opt: 858 z-score: 1317.7 E(): 0, 52.0% identity in 227 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03976 Domain of unknown function (DUF344) was identified within CDS This Pfam has now been modified to Polyphosphate kinase 2. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score ha [...]
  
    0.659
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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