Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Cj0791cPutative aminotransferase; Original (2000) note: Cj0791c, probable aminotransferase, len: 424 aa; similar to many members of the nifS family e.g. TR:O32164 (EMBL:Z99120) B. subtilis YURW protein (406 aa), fasta scores; opt: 289 z-score: 340.6 E(): 1.1e-11, 23.9% identity in 431 aa overlap. 45.4% identity to HP0405. Contains PS00455 Putative AMP-binding domain signature and PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site; Updated (2006) note: No specific characterisation with acceptable identity score carried out yet. Putative kept within product function. Function [...] (424 aa)    
Predicted Functional Partners:
Cj0239c
NifU protein homolog; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.
  
 0.993
Cj0118
Conserved hypothetical protein Cj0118; Original (2000) note: Cj0118, unknown, len: 251 aa; similar to hypothetical proteins from many organisms e.g. YDAO_ECOLI (311 aa), fasta scores; opt: 447 z-score: 465.6 E(): 1.1e-18, 32.5% identity in 240 aa overlap. 49.4% identity to HP1182. Contains Pfam match to entry PF01171 UPF0021, Uncharacterized protein family UPF0021, score -88.80, E-value 9.9e-05; Updated (2006) note: Pfam domain PF01171 PP-loop family identified within CDS. No specific characterisation has been carried out. Thus, putative kept within product function. Conserved added to [...]
 
    0.915
cdtB
Original (2000) note: Cj0078c, cdtB, cytolethal distending toxin, len: 265 aa; identical toTR:Q46101 (EMBL:U51121) cdtB (265 aa) and similar to e.g. TR:Q47089 (EMBL:U03293) Escherichia coli cdtB (273 aa), fasta scores; opt: 946 z-score: 1533.6 E(): 0, 55.2% identity in 268 aa overlap. No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Prosite domain PRO1388 CDTOXINB, Cytolethal distending toxin B signature identified within CDS. Product modified to more specific family member due to motif match. Characterised within Campylobacter jejuni, so putative not added to pro [...]
    
   0.797
Cj0792
Conserved hypothetical protein Cj0792; Original (2000) note: Cj0792, unknown, len: 292 aa; some similarity to hypothetical proteins e.g. YZ04_METJA hypothetical protein MJECL04 (439 aa), fasta scores; opt: 175 z-score: 208.0 E(): 0.00027, 26.5% identity in 309 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF03008 Archaea bacterial proteins of unknown function identified within CDS. Conserved added to product function. Functional classification - Conserved hypothetical proteins.
       0.659
flgS
Original (2000) note: Cj0793, probable signal transduction histidine kinase, len: 339 aa; similar to e.g. the C-terminus of ATOS_ECOLI sensor protein ATOS (608 aa), fasta scores; opt: 357 z-score: 408.3 E(): 1.9e-15,33.3% identity in 222 aa overlap. 42.4% identity to HP0244. Contains Pfam match to entry PF00512 signal,Signal carboxyl-terminal domain; Updated (2006) note: Characterised within Campylobacter jejuni and Helicobacter pylori. Putative not added to product function. Literature search identified papers linking Cj0793 and Cj1024 to a two-component signal transduction system (Fl [...]
       0.659
Cj1476c
Original (2000) note: Cj1476c, probable pyruvate-flavodoxin oxidoreductase, len: 1186 aa; highly similar to many e.g. NIFJ_ECOLI probable pyruvate-flavodoxin oxidoreductase (1174 aa), fasta scores; opt: 3586 z-score: 3799.5 E(): 0, 47.2% identity in 1193 aa overlap. N-term has 28.6% identity to HP1110,C-term has 29.7% identity to HP1111. Contains 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature,and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: Pfam domains PF02775 Thiamine pyrophosphate enzy [...]
  
  
 0.577
selD
Putative selenide,water dikinase; Synthesizes selenophosphate from selenide and ATP.
    
 0.547
gltB
Original (2000) note: Cj0007, gltB, probable glutamate synthase (NADPH) large subunit, len: 1496 aa; similar to many e.g. GLTB_ECOLI glutamate synthase (NADPH) large chain (1517 aa), fasta scores; opt: 3846 z-score: 3828.3 E(): 0, 42.5% identity in 1488 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF00310 Glutamine amidotransferases class-II, PF04898 Glutamate synthase central domain, PF01645 Conserved region in glutamate synthase and PF01493 GXGXG motif were all identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...]
  
  
 0.512
trxB
Thioredoxin reductase; Original (2000) note: Cj0146c, trxB, probable thioredoxin reductase, len: 312 aa; similar to many e.g. TRXB_LISMO thioredoxin reductase (EC 1.6.4.5) (319 aa),fasta scores; opt: 749 z-score: 926.7 E(): 0, 38.0% identity in 313 aa overlap. 64.2% identity to HP0825. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site; Updated (2006) note: Pfam domain PF00070 Pyridine nucleotide-disulphide oxidoreductase identified within CDS. Further support given to product function. Characterised within Listeria monocytogenes with acceptable identi [...]
   
 
  0.495
Cj0559
Original (2000) note: Cj0559, probable oxidoreductase, len: 311 aa; similar to members of the pyridine nucleotide-disulfide oxidoreductases class-II family e.g. R34K_CLOPA 34.2 KD protein in rubredoxin operon (308 aa), fasta scores; opt: 217 z-score: 335.8 E(): 2.1e-11, 23.2% identity in 314 aa overlap, and TRXB_BACSU thioredoxin reductase (315 aa), fasta scores; opt: 192 z-score: 279.9 E(): 2.7e-08, 25.9% identity in 313 aa overlap. 46.3% identity to HP1164. Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated (2006) [...]
   
 
  0.495
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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