Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
serAOriginal (2000) note: Cj0891c, serA, probable D-3-phosphoglycerate dehydrogenase, len: 527 aa; similar to e.g. SERA_BACSU D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) (525 aa), fasta scores; opt: 1151 z-score: 1318.2 E(): 0, 36.4% identity in 528 aa overlap. 50.7% identity to HP0397. Also similar to Cj0373 (30.1% identity in 309 aa overlap). Contains PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature, S00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2, and Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases [...] (527 aa)    
Predicted Functional Partners:
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 0.990
Cj1476c
Original (2000) note: Cj1476c, probable pyruvate-flavodoxin oxidoreductase, len: 1186 aa; highly similar to many e.g. NIFJ_ECOLI probable pyruvate-flavodoxin oxidoreductase (1174 aa), fasta scores; opt: 3586 z-score: 3799.5 E(): 0, 47.2% identity in 1193 aa overlap. N-term has 28.6% identity to HP1110,C-term has 29.7% identity to HP1111. Contains 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature,and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: Pfam domains PF02775 Thiamine pyrophosphate enzy [...]
  
 
 0.926
rpsA
30S ribosomal protein S1; Original (2000) note: Cj0893c, rpsA, probable 30S ribosomal protein S1, len: 556 aa; similar to many e.g. RS1_ECOLI 30S ribosomal protein S1 (557 aa), fasta scores; opt: 1053 z-score: 1148.3 E(): 0, 33.4% identity in 548 aa overlap. 47.0% identity to HP0399. Contains 6x Pfam match to entry PF00575 S1, S1 RNA binding domain; Updated (2006) note: Characterised in Escherichia coli with marginal identity score. Appropriate motifs present. Putative not added to product function. Functional classification - Ribosomal protein synthesis and modification; PMID:6267426.
  
  
 0.826
Cj0892c
Putative periplasmic protein; Original (2000) note: Cj0892c, probable periplasmic protein, len: 162 aa; no Hp match. Functional classification - Miscellaneous periplasmic proteins.
       0.822
Cj0888c
Original (2000) note: Cj0888c, ABC transport system ATP-binding protein, len: 643 aa; similar to UUP_ECOLI ABC transporter atp-binding protein UUP (635 aa), fasta scores; opt: 744 z-score: 763.9 E(): 0, 37.1% identity in 634 aa overlap. No Hp ortholog. Contains 2x PS00017 ATP/GTP-binding site motif A (P-loop), 2x PS00211 ABC transporters family signature, and 2x Pfam match to entry PF00005 ABC_tran; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification -Transport/binding proteins - Ot [...]
       0.814
Cj0890c
Original (2000) note: Cj0890c, probable sensory transduction transcriptional regulator, len: 220 aa; similar to many e.g. PHOB_SHIFL phosphate regulon transcriptional regulator (229 aa), fasta scores; opt: 396 z-score: 471.5 E(): 5.8e-19, 29.3% identity in 222 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain and Pfam match to entry PF00486 trans_reg_C,Transcriptional regulatory protein, C terminal; Updated (2006) note: Characterisation within more than one genus, however, identity scores were marginal. Putative kept withi [...]
       0.813
Cj0889c
Original (2000) note: Cj0889c, probable sensory transduction histidine kinase, len: 429 aa; similar in C-terminus to many e.g. ENVZ_ECOLI osmolarity sensor protein ENVZ (450 aa), fasta scores; opt: 210 z-score: 229.3 E(): 1.8e-05. 26.5% identity in 204 aa overlap No Hp ortholog. Contains two probable transmembrane domains in N-terminus and Pfam match to entry PF00512 signal, Signal carboxyl-terminal domain; Updated (2006) note: Pfam domain PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase identified within CDS. Further support given to product function. Some characterisat [...]
       0.773
rplF
50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
    
   0.772
fliM
Flagellar motor switch protein; Original (2000) note: Cj0060c, fliM, probable flagellar motor switch protein, len: 359 aa; simlar to e.g. FLIM_BACSU flagellar motor switch protein fliM (332 aa), fasta scores; opt: 728 z-score: 1046.5 E(): 0, 35.6% identity in 329 aa overlap. 61.1% identity to HP1031; Updated (2006) note: Pfam domain PF01052 Surface presentation of antigens (SPOA) protein and PF02154 Flagellar motor switch protein FliM were identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with acceptable identity score. Thus, putat [...]
    
   0.761
cysM
Cysteine synthase; Original (2000) note: Cj0912c, cysM, cysteine synthase, len: 299 aa; 98.7% identical to CYSM_CAMJE cysteine synthase B (EC 4.2.99.8) (299 aa), and similar to many e.g. CYSK_BACSU CYSTEINE SYNTHASE (EC 4.2.99.8) (307 aa), fasta scores; opt: 907 z-score: 1020.2 E(): 0, 48.5% identity in 305 aa overlap. 38.9% identity to HP0107. Contains PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site, PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site, and Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependant [...]
  
 0.755
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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