STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
serAOriginal (2000) note: Cj0891c, serA, probable D-3-phosphoglycerate dehydrogenase, len: 527 aa; similar to e.g. SERA_BACSU D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) (525 aa), fasta scores; opt: 1151 z-score: 1318.2 E(): 0, 36.4% identity in 528 aa overlap. 50.7% identity to HP0397. Also similar to Cj0373 (30.1% identity in 309 aa overlap). Contains PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature, S00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2, and Pfam match to entry PF00389 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenases [...] (527 aa)    
Predicted Functional Partners:
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 0.982
Cj1476c
Original (2000) note: Cj1476c, probable pyruvate-flavodoxin oxidoreductase, len: 1186 aa; highly similar to many e.g. NIFJ_ECOLI probable pyruvate-flavodoxin oxidoreductase (1174 aa), fasta scores; opt: 3586 z-score: 3799.5 E(): 0, 47.2% identity in 1193 aa overlap. N-term has 28.6% identity to HP1110,C-term has 29.7% identity to HP1111. Contains 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature,and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: Pfam domains PF02775 Thiamine pyrophosphate enzy [...]
  
 
 0.884
rplF
50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
   
   0.879
rplB
50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
   
   0.850
rplQ
50S ribosomal protein L17; Original (2000) note: Cj1596, rplQ, probable 50S ribosomal protein L17, len: 117 aa; similar to many e.g. RL17_ECOLI 50S ribosomal protein L17 (127 aa), fasta scores; opt: 346 z-score: 460.2 E(): 2.6e-18, 49.1% identity in 116 aa overlap. 73.3% identity to HP1292. Contains PS01167 Ribosomal protein L17 signature, and Pfam match to entry PF01196 Ribosomal_L17, Ribosomal protein L17; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification -Ribosomal protein synt [...]
    
   0.844
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
   0.835
rplP
50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.
   
   0.834
rpmA
Original (2000) note: Cj0095, rpmA, 50S ribosomal protein L27, len: 84 aa; highly similar to meny e.g. RL27_ECOLI 50S ribosomal protein L27 (84 aa), fasta scores; opt: 334 z-score: 627.0 E(): 1.1e-27, 65.4% identity in 81 aa overlap. 85.2% identity to HP0297. Contains PS00831 Ribosomal protein L27 signature and Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein, score 189.40, E-value 5.5e-53; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Thus,putative not added to product function. Functional classification - Ribosomal protein [...]
  
   0.832
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
   
   0.829
rplV
50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
   
 
 0.829
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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