STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hipOHippurate hydrolase; Cleaves hippuric acid into benzoic acid and glycine. Belongs to the peptidase M20 family. (383 aa)    
Predicted Functional Partners:
gltB
Original (2000) note: Cj0007, gltB, probable glutamate synthase (NADPH) large subunit, len: 1496 aa; similar to many e.g. GLTB_ECOLI glutamate synthase (NADPH) large chain (1517 aa), fasta scores; opt: 3846 z-score: 3828.3 E(): 0, 42.5% identity in 1488 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF00310 Glutamine amidotransferases class-II, PF04898 Glutamate synthase central domain, PF01645 Conserved region in glutamate synthase and PF01493 GXGXG motif were all identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...]
  
 
  0.800
Cj0986c
Original (2000) note: Cj0986c, possible integral membrane protein, len: 62 aa; 98.4% identical to C-terminus of YHI2_CAMJE hypothetical protein (203 aa). No Hp match; Updated (2006) note: Two probable transmembrane helices predicted for Cj0986c by TMHMM2.0. Functional classification - Membranes, lipoproteins and porins.
  
    0.774
lysC
Original (2000) note: Cj0582, lysC, probable aspartokinase, alpha and beta subunits, len: 400 aa; highly simlar to many e.g. AKAB_CORGL aspartokinase alpha and beta subunits (EC 2.7.2.4) (421 aa), fasta scores; opt: 1228 z-score: 1715.1 E(): 0, 48.9% identity in 405 aa overlap. 63.0% identity to HP1229. Contains PS00324 Aspartokinase signature and Pfam match to entry PF00696 aakinase, Aspartate kinases, Glutamate kinases and Gamma glutamate phospho-reductases; Updated (2006) note: Characterised within Bacillus subtilis with acceptable identity score. Putative not added to product funct [...]
     
 0.628
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).
   
  
 0.619
Cj0987c
Putative MFS (Major Facilitator Superfamily) transport protein; Original (2000) note: Cj0987c, probable integral membrane protein, len: 321 aa; identical to N- and C-terminus of YHI2_CAMJE hypothetical protein (203 aa),which has a central deletion relative to this CDS. Some similarity to hypothetical membrane proteins e.g. YJHB_ECOLI (405 aa), fasta scores; opt: 239 z-score: 285.2 E(): 1.4e-08, 24.6% identity in 301 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily identified within CDS. Also, nine probable transmembrane helices predicted b [...]
  
    0.594
ceuE
Original (2000) note: Cj1355, ceuE, probable enterochelin uptake periplasmic binding protein, len: 330 aa; highly similar to TR:Q46006 (EMBL:X88849) Campylobacter coli ceuE (328 aa), fasta scores; opt: 1903 z-score: 2111.3 E(): 0, 90.6% identity in 330 aa overlap,and similar to e.g. FATB_VIBAN ferric anguibactin-binding protein precursor (322 aa), fasta scores; opt: 540 z-score: 605.4 E(): 2e-26, 30.1% identity in 279 aa overlap. No Hp match. Contains probable N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site; Updated [...]
      
 0.580
Cj0988c
Very hypothetical protein Cj0988c; Original (2000) note: Cj0988c, questionable CDS,len: 78 aa; 98.3% identical to TR:Q46117 (EMBL:Z36940) C. jejuni hypothetical protein. No Hp match; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Unknown.
  
    0.572
cadF
Original (2000) note: Cj1478c, cadF, outer membrane fibronectin-binding protein, len: 319 aa; 82.8% identical to TR:O06895 (EMBL:U87559) C. jejuni CADF precursor (fibronectin-binding protein) (326 aa), and similar to many oprF proteins e.g. PORF_PSEFL outer membrane porin F precursor (root adhesin) (326 aa), fasta scores; opt: 401 z-score: 458.6 E(): 3.2e-18, 29.1% identity in 316 aa overlap. No Hp match. Contains PS01068 OmpA-like domain,and Pfam match to entry PF00691 OmpA, OmpA family; Updated (2006) note: Characterised within Campylobacter jejuni, so putative not added to product f [...]
      
 0.545
cdtA
Cytolethal distending toxin A; CDTs are cytotoxins which induce cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.
      
 0.524
lpxA
acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
      
 0.509
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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