Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Cj1007cPutative mechanosensitive ion channel family protein; Original (2000) note: Cj1007c, probable membrane protein, len: 523 aa; similar in C-terminus to hypothetical proteins e.g. Y700_METJA hypothetical protein MJ0700 (324 aa), fasta scores; opt: 281 z-score: 300.2 E(): 2e-09, 29.0% identity in 276 aa overlap. 37.4% identity to HP0284; Updated (2006) note: Pfam domain PF00924 Mechanosensitive ion channel identified within CDS. Also,three probable transmembrane helices predicted by TMHMM2.0. Product modified to more specific family member based on motif match. No specific characterisation [...] (523 aa)    
Predicted Functional Partners:
Cj1009c
Conserved hypothetical proetin Cj1009c; Original (2000) note: Cj1009c, unknown, len: 466 aa; 29.1% identity to HP0282; Updated (2006) note: Pfam domain PF02080 TrkA-C domain identified within CDS. The TrkA-C domain is typically found next to the -N domain. Currently unknown function. Functional classification - Conserved hypothetical proteins.
 
     0.878
Cj1005c
Original (2000) note: Cj1005c, probable membrane bound ATPase, len: 538 aa; similar to many members of the AAA family e.g. FTSH_BACSU cell division protein FTSH homolog (EC 3.4.24.-) (637 aa), fasta scores; opt: 901 z-score: 909.6 E(): 0, 36.3% identity in 518 aa overlap. 43.8% identity to HP0286. Also similar to ftsH Cj1116c (36.2% identity in 578 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00674 AAA-protein family signature, and Pfam match to entry PF00004 AAA,ATPases associated with various cellular activities (AAA); Updated (2006) note: Pfam domain PF0648 [...]
 
     0.842
Cj1006c
Putative MiaB-like tRNA modifying enzyme; Original (2000) note: Cj1006c, unknown, len: 416 aa; similar to hypothetical proteins belonging to the UPF0004 family e.g. Y16R_MYCIO (438 aa), fasta scores; opt: 580 z-score: 664.7 E(): 1e-29, 30.5% identity in 413 aa overlap. 50.1% identity to HP0285. Also similar to Cj0458c (28.6% identity in 391 aa overlap) and Cj1454c (28.4% identity in 419 aa overlap). Contains PS01278 Uncharacterized protein family UPF0004 signature and Pfam match to entry PF00919 UPF0004; Updated (2006) note: Pfam domain PF04055 Radical SAM superfamily identified within [...]
       0.822
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
       0.822
atpF-2
ATP synthase F0 sector B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family.
  
     0.729
Cj0957c
Hypothetical protein Cj0957c; Original (2000) note: Cj0957c, unknown, len: 272 aa; 42.5% identity to HP1451. Functional classification -Conserved hypothetical proteins.
  
     0.729
Cj0313
Original (2000) note: Cj0313, probable integral membrane protein, len: 352 aa; 35.9% identity to HP1498; Updated (2006) note: Pfam domains PF03739 Predicted permease YjgP/YjgQ family were identified. Members of this family are predicted integral membrane proteins of unknown function. They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this. Six probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, lipoprotei [...]
  
     0.721
Cj1712
Hypothetical protein Cj1712; Original (2000) note: Cj1712, unknown, len: 178 aa; 40.9% identity to HP1530 (called purine nucleoside phosphorylase (punB). Functional classification -Conserved hypothetical proteins.
  
     0.711
hemD
Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
     0.708
moaE
Original (2000) note: Cj1518, moaE, possible molybdopterin converting factor, subunit 2, len: 148 aa; similar to many predicted moaE genes, e.g. TR:O31705 (EMBL:AF012285) Bacillus subtilis molybdopterin converting factor (subunit 2) (157 aa), fasta scores; opt: 134 z-score: 182.4 E(): 0.0078, 25.2% identity in 131 aa overlap, and to MOAE_ECOLI molybdopterin [mpt] converting factor, subunit 2 (149 aa), fasta scores opt: 133 z-score: 181.4 E(): 0.0087, 26.0% identity in 123 aa overlap. 50.4% identity to HP0800; Updated (2006) note: Pfam domain PF02391 MoaE protein identified within CDS. [...]
  
     0.680
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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