STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa)    
Predicted Functional Partners:
lysC
Original (2000) note: Cj0582, lysC, probable aspartokinase, alpha and beta subunits, len: 400 aa; highly simlar to many e.g. AKAB_CORGL aspartokinase alpha and beta subunits (EC 2.7.2.4) (421 aa), fasta scores; opt: 1228 z-score: 1715.1 E(): 0, 48.9% identity in 405 aa overlap. 63.0% identity to HP1229. Contains PS00324 Aspartokinase signature and Pfam match to entry PF00696 aakinase, Aspartate kinases, Glutamate kinases and Gamma glutamate phospho-reductases; Updated (2006) note: Characterised within Bacillus subtilis with acceptable identity score. Putative not added to product funct [...]
 
 
 0.973
hom
Homoserine dehydrogenase; Original (2000) note: Cj0149c, hom, probable homoserine dehydrogenase, len: 415 aa; similar to many e.g. DHOM_BACSU homoserine dehydrogenase (EC 1.1.1.3) (433 aa), fasta scores; opt: 932 z-score: 1191.7 E(): 0, 36.4% identity in 426 aa overlap. 53.3% identity to HP0822. Contains PS01042 Homoserine dehydrogenase signature and Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase, score 329.20, E-value 4.7e-95; Updated (2006) note: Characterised within Bacillus subtilis with acceptable identity score. Putative not added to product function. Functio [...]
 
 0.952
dapA-2
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.913
Cj1022c
Original (2000) note: Cj1022c, probable integral membrane protein, len: 168 aa; similar to e.g. TR:O66639 (EMBL:AE000682) Aquifex aeolicus AQ_286 (175 aa), fasta scores; opt: 354 z-score: 451.1 E(): 7.9e-18, 34.3% identity in 166 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF07053 Protein of unknown function (DUF1334) identified within CDS. Also,four probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, lipoproteins and porins.
  
  
 0.891
dapA
Putative dihydrodipicolinate synthase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Belongs to the DapA family.
 
 
 0.875
flgR
Sigma-54 associated transcriptional activator; Original (2000) note: Cj1024c, probable signal-transduction regulatory protein, len: 433 aa; similar to e.g. NTRC_PROVU nitrogen regulation protein NR(I) (473 aa), fasta scores; opt: 957 z-score: 1002.5 E(): 0, 38.8% identity in 397 aa overlap, and ATOC_ECOLI acetoacetate metabolism regulatory protein (461 aa), fasta scores; opt: 929 z-score: 973.5 E(): 0, 38.2% identity in 453 aa overlap. 57.1% identity to HP0703. Contains Pfam match to entry PF00072 response_reg, Response regulator receiver domain, PS00675 and PS00676 Sigma-54 interactio [...]
  
  
 0.875
pgk
Phosphoglycerate kinase; Original (2000) note: Cj1402c, pgk,phosphoglycerate kinase, len: 400 aa; similar to e.g. PGK_AQUAE phosphoglycerate kinase (EC 2.7.2.3) (397 aa),fasta scores; opt: 1417 z-score: 1610.9 E(): 0, 53.4% identity in 393 aa overlap, and PGKY_WHEAT phosphoglycerate kinase, cytosolic (401 aa), fasta scores; opt: 1369 z-score: 1556.5 E(): 0, 53.1% identity in 392 aa overlap. 49.1% identity to HP1345. Contains PS00111 Phosphoglycerate kinase signature, and Pfam match to entry PF00162 PGK, Phosphoglycerate kinases; Updated (2006) note: Characterisation work carried out in [...]
  
 0.838
gltB
Original (2000) note: Cj0007, gltB, probable glutamate synthase (NADPH) large subunit, len: 1496 aa; similar to many e.g. GLTB_ECOLI glutamate synthase (NADPH) large chain (1517 aa), fasta scores; opt: 3846 z-score: 3828.3 E(): 0, 42.5% identity in 1488 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF00310 Glutamine amidotransferases class-II, PF04898 Glutamate synthase central domain, PF01645 Conserved region in glutamate synthase and PF01493 GXGXG motif were all identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...]
  
  
 0.828
dapB
Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
 
  
 0.794
Cj1476c
Original (2000) note: Cj1476c, probable pyruvate-flavodoxin oxidoreductase, len: 1186 aa; highly similar to many e.g. NIFJ_ECOLI probable pyruvate-flavodoxin oxidoreductase (1174 aa), fasta scores; opt: 3586 z-score: 3799.5 E(): 0, 47.2% identity in 1193 aa overlap. N-term has 28.6% identity to HP1110,C-term has 29.7% identity to HP1111. Contains 2x PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature,and Pfam match to entry PF00037 fer4, 4Fe-4S ferredoxins and related iron-sulfur cluster binding domains; Updated (2006) note: Pfam domains PF02775 Thiamine pyrophosphate enzy [...]
   
 
  0.791
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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