Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Cj1237cPutative phosphatase; Original (2000) note: Cj1237c, possible phosphatase, len: 324 aa; weak similarity to e.g. GPPA_ECOLI guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (494 aa), fasta scores; opt: 174 z-score: 201.9 E(): 0.0006, 25.7% identity in 323 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF02541 Ppx/GppA phosphatase family was identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score carried out yet, so putative kept within product function (previously was posssible). Functional classifi [...] (324 aa)    
Predicted Functional Partners:
Cj0353c
Phosphatase; Original (2000) note: Cj0353c, probable phosphatase, len: 486 aa; similar to e.g. GPPA_ECOLI guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC 3.6.1.40) (494 aa), fasta scores; opt: 368 z-score: 272.7 E(): 6.2e-08, 25.8% identity in 480 aa overlap, and to PPX_ECOLI EXOPOLYPHOSPHATASE (EC 3.6.1.11) (512 aa),fasta scores; opt: 340 z-score: 350.9 E(): 2.7e-12, 23.8% identity in 441 aa overlap. 41.0% identity to HP0278; Updated (2006) note: Pfam domain PF02541 Ppx/GppA phosphatase family identified within CDS. Further support given to product function. Similar to ma [...]
  
  
 
0.815
spoT
Putative guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.804
flgG2
Flagellar basal-body rod protein; Original (2000) note: Cj0697, flgG2, probable flagellar basal-body rod protein, len: 270 aa; similar to e.g. FLGG_ECOLI flagellar basal-body rod protein FLGG (260 aa), fasta scores; opt: 290 z-score: 318.7 E(): 1.9e-10,28.7% identity in 272 aa overlap. 42.6% identity to HP1092. Also similar to downstream gene Cj0698 (flgG,29.9% identity in 281 aa overlap). Contains PS00588 Flagella basal body rod proteins signature and Pfam match to entry PF00460 flg_bb_rod, Flagella basal body rod proteins; Updated (2006) note: Characterised within Escherichia coli wi [...]
    
   0.761
pdxJ
Pyridoxal phosphate biosynthetic protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
       0.656
pdxA
Putative 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
  
    0.656
ppk
Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family.
 
  
 0.656
Cj0499
Putative histidine triad (HIT) family protein; Original (2000) note: Cj0499, unknown, len: 161 aa; similar to many members of the HIT family e.g. HIT_BACSU HIT protein (145 aa), fasta scores; opt: 176 z-score: 274.7 E(): 5.2e-08, 26.1% identity in 111 aa overlap. 42.6% identity to HP0741. Contains Pfam match to entry PF01230 HIT, HIT family, score 19.90, E-value 3.6e-06; Updated (2006) note: Product modified to more specific family member due to motif match. No specific characterisation has been carried out yet. Putative kept within product function. Functional classification - Misc.
  
 
 
 0.468
gltB
Original (2000) note: Cj0007, gltB, probable glutamate synthase (NADPH) large subunit, len: 1496 aa; similar to many e.g. GLTB_ECOLI glutamate synthase (NADPH) large chain (1517 aa), fasta scores; opt: 3846 z-score: 3828.3 E(): 0, 42.5% identity in 1488 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF00310 Glutamine amidotransferases class-II, PF04898 Glutamate synthase central domain, PF01645 Conserved region in glutamate synthase and PF01493 GXGXG motif were all identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with [...]
     
 0.457
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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