STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cj1321Putative transferase; Original (2000) note: Cj1321, probable transferase,len: 180 aa; similar to TR:Q46674 (EMBL:U05248) E. coli polysialic acid gene cluster region 2 neuD (207 aa), fasta scores; opt: 267 z-score: 337.2 E(): 1.8e-11, 29.6% identity in 162 aa overlap, some simialrity to e.g. LPXA_BRUAB acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (283 aa), fasta scores; opt: 134 z-score: 173.4 E(): 0.025, 31.6% identity in 95 aa overlap. No Hp match. Also similar to Cj1123c wlaI (30.2% identity in 179 aa overlap). Contains 2x Pfam match to entry PF00132 hexapep [...] (180 aa)    
Predicted Functional Partners:
Cj1323
Hypothetical protein Cj1323; Original (2000) note: Cj1323, unknown, len: 128 aa; no Hp match; Updated (2006) note: Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Literature search identified paper linking Cj1321-Cj1326 as being a glycosylation islet (PMID:16230626). Functional classification - Unknown; PMID:16230626, PMID:16573682, PMID:12781527.
  
  
 0.956
Cj1324
Hypothetical protein Cj1324; Original (2000) note: Cj1324, unknown, len: 373 aa; some similarity to TR:P72140 (EMBL:U50396) Pseudomonas aeruginosa WBPG (lipopolysaccharide gene cluster) (376 aa), fasta scores; opt: 166 z-score: 199.7 E(): 0.0008,20.1% identity in 378 aa overlap. No Hp match. Also similar to Cj1316c; Updated (2006) note: Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Literature search identified paper linking Cj1321-Cj1326 as being a glycosylation islet (PMID:16230626). Also shows some similarity to Cj1316 pseudaminic acid bios [...]
  
  
 0.915
Cj1322
Hypothetical protein Cj1322; Original (2000) note: Cj1322, unknown, len: 106 aa; no Hp match; Updated (2006) note: Identifed as part of Campylobacter jejuni O-linked glycosylation locus (Cj1293 - Cj1342). Literature search identified paper linking Cj1321-Cj1326 as being a glycosylation islet (PMID:16230626). Functional classification - Unknown; PMID:16230626, PMID:12586395, PMID:16573682,PMID:12781527.
  
    0.779
Cj1325
Putative methyltransferase; Original (2000) note: Cj1326, unknown, len: 140 aa; no Hp match. Contains polyporphic sequence G(9-10) at N-terminus; G(9) allows translation from the upstream CDS Cj1325, G(10) (consensus) would only allow this CDS to start at aa 22. Similar to Cj0171 (51.9% identity in 135 aa overlap), which also contains a polymorphic sequence allowing possible translation from Cj0170; Original (2000) note: Cj1325, unknown, len: 89 aa; no Hp match. Contains polyporphic sequence G(9-10) at C-terminus; G(10) (consensus) gives this translation stop,G(9) allows translation in [...]
  
  
 0.768
Cj1320
Putative aminotransferase (degT family); Original (2000) note: Cj1320, probable aminotransferase, len: 384 aa; similar to members of the degT family e.g. TR:Q06953 (EMBL:X59554) Vibrio cholerae RFBE protein (367 aa), fasta scores; opt: 315 z-score: 377.4 E(): 1e-13, 32.7% identity in 361 aa overlap. No Hp ortholog. Contains Pfam match to entry PF01041 DegT_DnrJ_EryC1, DegT/DnrJ/EryC1/StrS family; Updated (2006) note: No specific characterisation with acceptable identity score has been carried out yet. Putative kept within product function. Identifed as part of Campylobacter jejuni O-li [...]
 
    0.766
maf1
Motility accessory factor (function unknown); Original (2000) note: Cj1318, unknown, len: 649 aa; no Hp ortholog, but 33.9% identity to HP0114. A member of the 1318 family of proteins. Similar to Cj1335/Cj1336 (100.0% identity in 59 aa overlap/100.0% identity in 592 aa overlap), Cj1333 (72.5% identity in 658 aa overlap),Cj1334 (41.5% identity in 648 aa overlap), Cj1337 (48.1% identity in 643 aa overlap), Cj1341c (30.2% identity in 640 aa overlap), Cj1340c (31.4% identity in 641 aa overlap). Contains G(10-11) polymorphic tract at aa 57. G(11) (consensus) gives this ORF, G(10) causes tru [...]
  
    0.736
Cj1319
Original (2000) note: Cj1319, probable nucleotide sugar dehydratase, len: 323 aa; similar to e.g. TR:Q54116 (EMBL:L37354) thymidine diphosphoglucose 4,6-dehydratase (329 aa), fasta scores; opt: 526 z-score: 600.3 E(): 3.9e-26, 29.5% identity in 315 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00106 adh_short,Alcohol/other dehydrogenases, short chain type; Updated (2006) note: Pfam domain now altered to PF01370 NAD dependent epimerase/dehydratase family. Further support given to product function. No specific characterisation with acceptable identity score carried out yet. [...]
 
    0.699
neuC2
Putative UDP-N-acetylglucosamine 2-epimerase; Involved in biosynthesis of legionaminic acid (5,7-diamino- 3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O- linkage to Ser/Thr. Catalyzes the conversion of GDP-N,N'- diacetylbacillosamine (Bac2Ac4Ac) into 2,4-diacetamido-2,4,6- trideoxymannose and GDP. It can also use UDP-N,N'-diacetylbacillosamine however it generates small quantities of 2,4-diacetamido-2,4,6- trideoxymannose.
 
    0.687
Cj1329
Original (2000) note: Cj1329, probable sugar-phosphate nucleotide transferase, len: 341 aa; similar in C-term (120 aa - end) to many predicted transferases, and to MPG1_YEAST mannose-1-phosphate guanyltransferase (361 aa), fasta scores; opt: 304 z-score: 343.2 E(): 8.1e-12, 28.9% identity in 225 aa overlap. N-term has some similarity to CBS domains in nucleotide dehydrogenases e.g. IMDH_BACSU inosine-5'-monophosphate dehydrogenase (513 aa), blastp scores; E=0.00034, 30% identity in 116 overlap. N-term contains 2x Pfam match to entry PF00571 CBS, CBS domain,C-term contains Pfam match to [...]
 
    0.679
maf3
Motility accessory factor (function unknown); Original (2000) note: Cj1334, unknown, len: 619 aa; no Hp ortholog, but 34.8% identity to HP0114. A member of the 1318 family of proteins. Similar to Cj1333 (41.9% identity in 645 aa overlap), Cj1318 (41.0% identity in 647 aa overlap), Cj1336 (41.9% identity in 590 aa overlap),Cj1337 (43.8% identity in 628 aa overlap), Cj1341c (34.3% identity in 621 aa overlap), and Cj1340c (34.0% identity in 618 aa overlap); Updated (2006) note: Pfam domain PF01973 Protein of unknown function DUF115 identified within CDS. Some characterisation work has bee [...]
  
    0.545
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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