STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hddAPutative D-glycero-D-manno-heptose 7-phosphate kinase; Original (2000) note: Cj1425c, possible sugar kinase, len: 339 aa; similar to e.g. GAL1_LACHE galactokinase (388 aa), fasta scores; opt: 186 z-score: 227.6 E(): 2.4e-05, 24.3% identity in 371 aa overlap. Contains PS00012 Phosphopantetheine attachment site. No Hp match; Updated (2006) note: Pfam domain PF00288 GHMP kinases putative ATP-binding protein identified within CDS. Further support given to product function. Literature search identified work carried out within Campylobacter jejuni. Not yet fully characterised, so putative ke [...] (339 aa)    
Predicted Functional Partners:
hddC
Putative D-glycero-D-manno-heptose 1-phosphate guanosyltransferase; Original (2000) note: Cj1423c, possible sugar-phosphate nucleotidyltransferase, len: 221 aa; similar to many predicted nucleotidyltransferases, e.g. TR:O58775 (EMBL:AP000004) Pyrococcus horikoshii hypothetical sugar-phosphate nucleotydyl transferase PH1022 (416 aa), fasta scores; opt: 413 z-score: 496.0 E(): 2.6e-20, 34.3% identity in 230 aa overlap, and MPG1_YEAST mannose-1-phosphate guanyltransferase (361 aa),fasta scores; opt: 258 z-score: 313.4 E(): 3.9e-10, 28.9% identity in 232 aa overlap. Contains Pfam match to [...]
 
 
 0.994
gmhA2
Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily.
 
 0.988
Cj1427c
Original (2000) note: Cj1427c, probable sugar-nucleotide epimerase/dehydratease, len: 313 aa; similar to many predicted epimerases/dehydrateases e.g. TR:Q25130 (EMBL:D25537) HALOCYNTHIA RORETZI (SEA SQUIRT) gene with similarity to UDPglucose4-epimerases and 3beta-hydroxysteroid dehydrogenase/isomerases HREPIB (241 aa), fasta scores; opt: 585 z-score: 691.2 E(): 3.5e-31,44.2% identity in 208 aa overlap, and TR:O73960 (EMBL:AP000002) Pyrococcus horikoshii hypothetical UDP-glucose 4-epimerase (318 aa), fasta scores; opt: 304 z-score: 361.7 E(): 7.9e-13, 26.4% identity in 326 aa overlap. N [...]
 
 
 0.983
Cj1426c
Putative methyltransferase family protein; Original (2000) note: Cj1426c, unknown, len: 283 aa; no Hp match. Contains C(10-11) polymorphic region at aa 99. C10 (consensus) gives this ORF, C11 gives truncation after +8 aa; Updated (2006) note: TIGRFAM motif TIGR01444 Methyltransferase FkbM, identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so putative kept within product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c -Cj1448c). Functional classification - Misc; P [...]
  
  
 0.969
rfbC
Putative dTDP-4-dehydrorhamnose 3,5-epimerase; Original (2000) note: Cj1430c, probable nucleotide-sugar epimerase/dehydratase, len: 181 aa; similar to e.g. RFBC_ECOLI DTDP-4-dehydrorhamnose 3,5-epimerase (185 aa), fasta scores; opt: 303 z-score: 386.2 E(): 3.4e-14, 33.9% identity in 165 aa overlap, and TR:Q46770 (EMBL:U23775) E. coli rmlC DTDP-6-deoxy-l-lyxo-4-hexulose reductase (183 aa), fasta scores; opt: 306 z-score: 390.0 E(): 2.1e-14, 33.5% identity in 164 aa overlap. No Hp match. Contains Pfam match to entry PF00908 dTDP_sugar_isom,dTDP-4-dehydrorhamnose 3,5-epimerase; Updated (2 [...]
 
  
 0.960
gmhB
D,D-heptose 1,7-bisphosphate phosphatase; Converts the D-glycero-alpha-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-alpha-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position; Belongs to the GmhB family.
 
 
 0.929
gmhA
Sedoheptulose 7-phosphate isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily.
 
 0.924
kfiD
UDP-glucose 6-dehydrogenase; Original (2000) note: Cj1441c, kfiD, probable UDP-glucose 6-dehydrogenase, len: 393 aa; similar to many e.g. UDG5_ECOLI UDP-glucose 6-dehydrogenase (EC 1.1.1.22) (392 aa), fasta scores; opt: 1386 z-score: 1511.4 E(): 0,52.3% identity in 392 aa overlap. No Hp match. Contains Pfam match to entry PF00984 UDPG_MGDP_dh,UDP-glucose/GDP-mannose dehydrogenase family; Updated (2006) note: Characterised within Escherichia coli with acceptable identity score. Putative removed from product function. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1 [...]
  
 
 0.884
Cj1429c
Hypothetical protein Cj1429c; Original (2000) note: Cj1429c, unknown, len: 308 aa; no Hp match. Contains C(9-10) polymorphic region at aa 98. C10 (consensus) gives this ORF, C9 would give truncation after +1 aa; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Unknown; PMID:15612919, PMID:10672176.
  
    0.879
Cj1433c
Hypothetical protein Cj1433c; Original (2000) note: Cj1433c, unknown, len: 368 aa; no Hp match. Contains 9 repeats of the aa sequence KIDLNNT near the N-terminus; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Identifed as part of Campylobacter jejuni capsule locus (Cj1413c - Cj1448c). Functional classification - Unknown; PMID:15612919, PMID:10672176.
  
    0.868
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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