STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cmeDOriginal (2000) note: Cj1031, possible outer membrane component of efflux system, len: 424 aa; similar to members of the PRTF family of secretion proteins e.g. TR:O68960 (EMBL:AF059041) putative outer membrane pore protein hefA (=HP0605) (477 aa), fasta scores; opt: 238 z-score: 261.5 E(): 2.9e-07, 25.2% identity in 409 aa overlap, and TOLC_SALEN outer membrane protein TOLC precursor (491 aa), fasta scores; opt: 174 z-score: 192.9 E(): 0.0019, 21.5% identity in 437 aa overlap. 24.8% identity to HP0605. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domains x2 P [...] (424 aa)    
Predicted Functional Partners:
cmeE
Original (2000) note: Cj1032, possible membrane fusion component of efflux system, len: 246 aa; similar to e.g. TR:O68961 EMBL:AF059041) H. pylori putative membrane fusion protein hefB (=HP0606) (241 aa), fasta scores; opt: 318 z-score: 369.4 E(): 2.8e-13, 35.5% identity in 248 aa overlap, and part of CZCB_ALCSP cation efflux system protein CZCB (520 aa), fasta scores; opt: 224 z-score: 258.9 E(): 4e-07, 28.6% identity in 213 aa overlap. Contains probable N-terminal signal sequence; Updated (2006) note: Pfam domain identified by running own Pfam search, PF00529 HlyD family secretion pr [...]
 
 0.995
cmeF
Original (2000) note: Cj1033, probable integral membrane component of efflux system, len: 1005 aa; similar to members of the ACRB/ACRD/ACRF family e.g. TR:O68962 (EMBL:AF059041) H. pylori putative RND pump protein hefC (=HP0607) (1026 aa), fasta scores; opt: 1372 z-score: 1439.0 E(): 0, 36.9% identity in 1027 aa overlap, and ACRD_ECOLI acriflavin resistance protein D (1037 aa),fasta scores; opt: 571 z-score: 598.0 E(): 5.2e-26, 25.7% identity in 1033 aa overlap. 37.1% identity to HP0607. Contains PS00017 ATP/GTP-binding site motif A (P-loop),and Pfam match to entry PF00873 ACR_tran, Ac [...]
  
 0.983
macB
ABC-type transmembrane transport protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.957
cmeA
Periplasmic fusion protein CmeA (multidrug efflux system CmeABC); Original (2000) note: Cj0367c, possible membrane fusion component of efflux system, len: 367 aa; similar to e.g. MTRC_NEIGO membrane fusion protein MTRC precursor (412 aa), fasta scores; opt: 592 z-score: 692.4 E(): 2.6e-31, 29.9% identity in 358 aa overlap, and TR:P95421 (EMBL:X99514) Pseudomonas aeruginosa mexE (antibiotic efflux system protein) (414 aa), fasta scores; opt: 460 z-score: 570.0 E(): 1.7e-24, 26.9% identity in 357 aa overlap. No Hp ortholog. Contains N-terminal signal sequence and PS00013 Prokaryotic memb [...]
  
 0.947
cmeB
Inner membrane efflux transporter CmeB (multidrug efflux system CmeABC); Original (2000) note: Cj0366c, probable transmembrane efflux protein, len: 1040 aa; similar to e.g. TR:P95422 (EMBL:X99514) Pseudomonas aeruginosa mexF (antibiotic efflux system protein) (1062 aa), fasta scores; opt: 1584 z-score: 3208.4 E(): 0, 41.2% identity in 1056 aa overlap, and ACRB_ECOLI acriflavin resistance protein B (1049 aa), fasta scores; opt: 2739 z-score: 3055.6 E(): 0, 41.7% identity in 1031 aa overlap. No Hp ortholog. Contains Pfam match to entry PF00873 ACR_tran,AcrB/AcrD/AcrF family, score 1415.1 [...]
  
 0.922
Cj0606
Putative secretion protein HlyD; Original (2000) note: Cj0606, probable periplasmic protein, len: 390 aa; similar to hypothetical proteins e.g. E. coli TR:P75830 (EMBL:AE000189) (380 aa), fasta scores; opt: 522 z-score: 648.1 E(): 8.4e-29, 31.3% identity in 386 aa overlap. No Hp ortholog. Contains probable N-terminal signal sequence and poly-Serine tract from aa 211 to 225; Updated (2006) note: Pfam domain PF00529 HlyD family secretion protein was identified within CDS. Literature search identified paper linking the putative three-gene operon Cj0606-0608) to a putative type-one secreti [...]
  
 0.872
cmeC
Outer membrane channel protein CmeC (multidrug efflux system CmeABC); Original (2000) note: Cj0365c, possible outer membrane channel protein, len: 492 aa; similar to members of the nodT/fusA family e.g. TR:O31101 (EMBL:AF029405) Pseudomonas putida outer membrane channel protein SRPC (470 aa), fasta scores; opt: 645 z-score: 834.4 E(): 0,29.2% identity in 465 aa overlap. and TR:Q51006 (EMBL:X95635) Neisseria gonorrhoeae mtrE gene (467 aa,fasta scores; opt: 663 z-score: 829.8 E(): 0, 31.1% identity in 476 aa overlap. No Hp match. Also some similarity to Cj0608 (28.6% identity in 455 aa o [...]
  
  
 0.835
Cj1178c
Highly acidic protein; Original (2000) note: Cj1178c, highly acidic protein, len: 542 aa; no Hp match. Very Asp- Glu- rich; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown.
  
 
 0.776
Cj0849c
Conserved hypothetical protein Cj0849c; Original (2000) note: Cj0849c, unknown, len: 719 aa; no Hp ortholog, some similarity to Cj0041 (23.1% identity in 566 aa overlap). Contain Asn-rich region near centre; Updated (2006) note: Prosite domain PS00063 Aldo/keto reductase family putative active site signature found within CDS. Functional classification - Conserved hypothetical proteins.
  
    0.773
Cj1643
Putative periplasmic protein; Original (2000) note: Cj1643, probable periplasmic protein, len: 364 aa; similar to hypothetical proteins e.g. TR:O34248 (EMBL:AJ003049) Wolinella succinogenes ORF341 protein (341 aa), fasta scores; opt: 238 z-score: 283.8 E(): 1.7e-08, 23.6% identity in 314 aa overlap. 25.5% identity to HP0036. Contains probable N-terminal signal sequence, and Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF); Updated (2006) note: Paper identified linking protein to glycoprotein. Functional classification -Miscellaneous periplasmic proteins; PMID:12186869.
  
    0.770
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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