SDM20112.1 protein (Kriegella aquimaris) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SDM20112.1

TonB-linked outer membrane protein, SusC/RagA family. (1066 aa)

Predicted Functional Partners:

SDM20140.1

0.941

SDL60368.1

0.770

SDL49382.1

0.769

SDM31033.1

0.766

SDL32943.1

0.763

SDM66506.1

0.760

SDM70763.1

0.755

SDN10961.1

0.733

SDM60391.1

0.727

SDM88428.1

0.702

Your Current Organism:

Kriegella aquimaris

NCBI taxonomy Id: 192904
Other names: DSM 19886, K. aquimaris, KCTC 22188, KMM 3665, Kriegella aquimaris Nedashkovskaya et al. 2008, Zobellia sp. KMM 3665

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDL32943.1	SDM20112.1	SAMN04488514_101421	SAMN04488514_10650	Starch-binding associating with outer membrane.	TonB-linked outer membrane protein, SusC/RagA family.	0.763
SDL32943.1	SDM31033.1	SAMN04488514_101421	SAMN04488514_107129	Starch-binding associating with outer membrane.	RagB/SusD domain-containing protein.	0.723
SDL49382.1	SDM20112.1	SAMN04488514_1011002	SAMN04488514_10650	Starch-binding associating with outer membrane.	TonB-linked outer membrane protein, SusC/RagA family.	0.769
SDL60368.1	SDM20112.1	SAMN04488514_10234	SAMN04488514_10650	Starch-binding associating with outer membrane.	TonB-linked outer membrane protein, SusC/RagA family.	0.770
SDM20112.1	SDL32943.1	SAMN04488514_10650	SAMN04488514_101421	TonB-linked outer membrane protein, SusC/RagA family.	Starch-binding associating with outer membrane.	0.763
SDM20112.1	SDL49382.1	SAMN04488514_10650	SAMN04488514_1011002	TonB-linked outer membrane protein, SusC/RagA family.	Starch-binding associating with outer membrane.	0.769
SDM20112.1	SDL60368.1	SAMN04488514_10650	SAMN04488514_10234	TonB-linked outer membrane protein, SusC/RagA family.	Starch-binding associating with outer membrane.	0.770
SDM20112.1	SDM20140.1	SAMN04488514_10650	SAMN04488514_10651	TonB-linked outer membrane protein, SusC/RagA family.	Starch-binding associating with outer membrane.	0.941
SDM20112.1	SDM31033.1	SAMN04488514_10650	SAMN04488514_107129	TonB-linked outer membrane protein, SusC/RagA family.	RagB/SusD domain-containing protein.	0.766
SDM20112.1	SDM60391.1	SAMN04488514_10650	SAMN04488514_11167	TonB-linked outer membrane protein, SusC/RagA family.	Starch-binding associating with outer membrane.	0.727
SDM20112.1	SDM66506.1	SAMN04488514_10650	SAMN04488514_11291	TonB-linked outer membrane protein, SusC/RagA family.	Starch-binding associating with outer membrane.	0.760
SDM20112.1	SDM70763.1	SAMN04488514_10650	SAMN04488514_11360	TonB-linked outer membrane protein, SusC/RagA family.	Starch-binding associating with outer membrane.	0.755
SDM20112.1	SDM88428.1	SAMN04488514_10650	SAMN04488514_11677	TonB-linked outer membrane protein, SusC/RagA family.	Starch-binding associating with outer membrane.	0.702
SDM20112.1	SDN10961.1	SAMN04488514_10650	SAMN04488514_1254	TonB-linked outer membrane protein, SusC/RagA family.	Starch-binding associating with outer membrane.	0.733
SDM20140.1	SDM20112.1	SAMN04488514_10651	SAMN04488514_10650	Starch-binding associating with outer membrane.	TonB-linked outer membrane protein, SusC/RagA family.	0.941
SDM31033.1	SDL32943.1	SAMN04488514_107129	SAMN04488514_101421	RagB/SusD domain-containing protein.	Starch-binding associating with outer membrane.	0.723
SDM31033.1	SDM20112.1	SAMN04488514_107129	SAMN04488514_10650	RagB/SusD domain-containing protein.	TonB-linked outer membrane protein, SusC/RagA family.	0.766
SDM31033.1	SDM70763.1	SAMN04488514_107129	SAMN04488514_11360	RagB/SusD domain-containing protein.	Starch-binding associating with outer membrane.	0.744
SDM60391.1	SDM20112.1	SAMN04488514_11167	SAMN04488514_10650	Starch-binding associating with outer membrane.	TonB-linked outer membrane protein, SusC/RagA family.	0.727
SDM66506.1	SDM20112.1	SAMN04488514_11291	SAMN04488514_10650	Starch-binding associating with outer membrane.	TonB-linked outer membrane protein, SusC/RagA family.	0.760

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.921

expected number of edges:

10

PPI enrichment p-value:

1.46e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016573

Histone acetylation

8 of 28

2.13

5.08

1.92e-12

GO:0043967

Histone H4 acetylation

5 of 8

2.47

4.13

8.49e-09

GO:0006325

Chromatin organization

10 of 238

1.29

2.05

3.53e-10

GO:0006974

Cellular response to DNA damage stimulus

10 of 278

1.23

1.82

1.28e-09

GO:0006281

DNA repair

9 of 230

1.26

1.81

1.73e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042393

Histone binding

4 of 51

1.56

0.96

0.0091

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035267

NuA4 histone acetyltransferase complex

11 of 18

2.46

10.04

2.20e-23

GO:0000118

Histone deacetylase complex

6 of 48

1.77

2.92

3.95e-08

GO:0000812

Swr1 complex

4 of 17

2.04

2.6

3.94e-06

GO:0000228

Nuclear chromosome

6 of 161

1.24

1.38

2.30e-05

GO:0000785

Chromatin

9 of 409

1.01

1.17

5.11e-07

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:19040720

(2008) Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

8 of 36

2.02

4.37

4.10e-11

PMID:37291101

(2023) A crucial role for dynamic expression of components encoding the negative arm of the circadian clock.

5 of 16

2.16

2.76

2.68e-06

PMID:30375921

(2019) Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes.

5 of 16

2.16

2.76

2.68e-06

PMID:25849764

(2015) AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex.

4 of 7

2.43

2.53

1.61e-05

PMID:29626083

(2018) The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes.

3 of 18

1.89

0.78

0.0330

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4384

H4 histone acetyltransferase complex

9 of 10

2.62

8.85

8.07e-19

CL:4338

INO80-type complex, and H4 histone acetyltransferase complex

10 of 33

2.15

6.95

3.25e-18

CL:4336

ATPase complex, and Sin3-type complex

11 of 79

1.81

5.12

9.20e-18

CL:4387

Histone H2A acetylation, and YEATS family

4 of 5

2.57

3.47

2.62e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035267

NuA4 histone acetyltransferase complex

11 of 14

2.56

10.88

2.46e-24

GOCC:0000118

Histone deacetylase complex

5 of 46

1.71

2.32

2.13e-06

GOCC:0000812

Swr1 complex

3 of 15

1.97

1.75

0.00030

GOCC:0000785

Chromatin

9 of 348

1.08

1.35

1.08e-07

GOCC:0070822

Sin3-type complex

2 of 15

1.79

0.9

0.0172

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0156

Chromatin regulator

10 of 104

1.65

3.75

6.64e-14

KW-0010

Activator

6 of 85

1.52

2.13

7.33e-07

KW-0227

DNA damage

7 of 158

1.32

1.74

7.33e-07

KW-0805

Transcription regulation

10 of 308

1.18

1.7

1.19e-09

KW-0234

DNA repair

6 of 129

1.34

1.62

6.51e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01408

Inhibitor of growth proteins N-terminal histone-binding

2 of 3

2.49

1.02

0.0135

SM00298

Chromatin organization modifier domain

2 of 9

2.02

0.77

0.0368

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