node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDL22499.1 | SDL46462.1 | SAMN04488514_10168 | SAMN04488514_101904 | Hydroxylysine kinase /5-phosphonooxy-L-lysine phospho-lyase apoenzyme. | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.884 |
SDL22499.1 | SDM62045.1 | SAMN04488514_10168 | SAMN04488514_111126 | Hydroxylysine kinase /5-phosphonooxy-L-lysine phospho-lyase apoenzyme. | Aldehyde dehydrogenase (NAD+). | 0.416 |
SDL22499.1 | gcvP | SAMN04488514_10168 | SAMN04488514_11436 | Hydroxylysine kinase /5-phosphonooxy-L-lysine phospho-lyase apoenzyme. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.877 |
SDL22499.1 | ilvA | SAMN04488514_10168 | SAMN04488514_10353 | Hydroxylysine kinase /5-phosphonooxy-L-lysine phospho-lyase apoenzyme. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.833 |
SDL22499.1 | phnW | SAMN04488514_10168 | SAMN04488514_111127 | Hydroxylysine kinase /5-phosphonooxy-L-lysine phospho-lyase apoenzyme. | 2-aminoethylphosphonate-pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. | 0.888 |
SDL46462.1 | SDL22499.1 | SAMN04488514_101904 | SAMN04488514_10168 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Hydroxylysine kinase /5-phosphonooxy-L-lysine phospho-lyase apoenzyme. | 0.884 |
SDL46462.1 | SDM62045.1 | SAMN04488514_101904 | SAMN04488514_111126 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Aldehyde dehydrogenase (NAD+). | 0.778 |
SDL46462.1 | gcvP | SAMN04488514_101904 | SAMN04488514_11436 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.628 |
SDL46462.1 | gcvT | SAMN04488514_101904 | SAMN04488514_12043 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.543 |
SDL46462.1 | glyA | SAMN04488514_101904 | SAMN04488514_101822 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.952 |
SDL46462.1 | ilvA | SAMN04488514_101904 | SAMN04488514_10353 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.898 |
SDL46462.1 | phnW | SAMN04488514_101904 | SAMN04488514_111127 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 2-aminoethylphosphonate-pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. | 0.908 |
SDL46462.1 | trpB-2 | SAMN04488514_101904 | SAMN04488514_11767 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.938 |
SDL86341.1 | gcvP | SAMN04488514_103196 | SAMN04488514_11436 | L-threonine aldolase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.924 |
SDL86341.1 | gcvT | SAMN04488514_103196 | SAMN04488514_12043 | L-threonine aldolase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.528 |
SDL86341.1 | glyA | SAMN04488514_103196 | SAMN04488514_101822 | L-threonine aldolase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.901 |
SDL86341.1 | ilvA | SAMN04488514_103196 | SAMN04488514_10353 | L-threonine aldolase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.882 |
SDL86341.1 | phnW | SAMN04488514_103196 | SAMN04488514_111127 | L-threonine aldolase. | 2-aminoethylphosphonate-pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. | 0.884 |
SDM62045.1 | SDL22499.1 | SAMN04488514_111126 | SAMN04488514_10168 | Aldehyde dehydrogenase (NAD+). | Hydroxylysine kinase /5-phosphonooxy-L-lysine phospho-lyase apoenzyme. | 0.416 |
SDM62045.1 | SDL46462.1 | SAMN04488514_111126 | SAMN04488514_101904 | Aldehyde dehydrogenase (NAD+). | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.778 |