STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AQU66026.1Homocysteine S-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)    
Predicted Functional Partners:
AQU69505.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
   
 
 0.948
AQU69861.1
Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.940
AQU66823.1
Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.937
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
   
 
 0.919
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
     
 0.919
AQU68363.1
Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.909
AQU65999.1
Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.905
AQU67375.1
Transcriptional regulator; Catalyzes the formation of homocysteine and pyruvate from cystathionine; also acts a a negative regulator for the mal regulon but interacting with the transcriptional activator MalT; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.902
AQU67436.1
Adenosylhomocysteinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.900
AQU68034.1
Adenosylhomocysteinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.900
Your Current Organism:
Streptomyces niveus
NCBI taxonomy Id: 193462
Other names: ATCC 19793, ATCC 23965 [[Streptomyces spheroides]], BCRC 11514, BCRC 11559 [[Streptomyces spheroides]], CBS 491.62 [[Streptomyces spheroides]], CBS 545.68, CBS 948.68 [[Streptomyces spheroides]], CCUG 11108, DSM 40088, DSM 40292 [[Streptomyces spheroides]], DSM 41788 [[Streptomyces laceyi]], IMET 43503, ISP 5088, ISP 5292 [[Streptomyces spheroides]], JCM 12606 [[Streptomyces laceyi]], JCM 4251, JCM 4252 [[Streptomyces spheroides]], JCM 4599, JCM 4670 [[Streptomyces spheroides]], LMG 19392 [[Streptomyces spheroides]], LMG 19395, LMG 5980, LMG:19392 [[Streptomyces spheroides]], LMG:19395, LMG:5980, NBRC 100783 [[Streptomyces laceyi]], NBRC 12804, NBRC 12917 [[Streptomyces spheroides]], NCIMB 11891 [[Streptomyces spheroides]], NCIMB 13928 [[Streptomyces laceyi]], NCIMB 9219, NRRL 2449 [[Streptomyces spheroides]], NRRL 2466, NRRL B-24638 [[Streptomyces laceyi]], NRRL-ISP 5088, NRRL-ISP 5292 [[Streptomyces spheroides]], RIA 700 [[Streptomyces spheroides]], S. niveus, Streptomyces laceyi, Streptomyces laceyi Manfio et al. 2003, Streptomyces spheroides, UNIQEM 179, strain C7654 [[Streptomyces laceyi]]
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