STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvBAcetolactate synthase large subunit. (576 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase small subunit.
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.997
leuB
3-isopropylmalate dehydrogenase.
 0.984
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 0.981
nifJ
Pyruvate-flavodoxin oxidoreductase.
  
 
 0.952
leuA_3
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.924
padG
NADH-dependent phenylglyoxylate dehydrogenase subunit alpha.
  
 
 0.917
korB
2-oxoglutarate oxidoreductase subunit KorB.
  
 
 0.916
leuA_1
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.898
maeB
NADP-dependent malic enzyme.
  
 
 0.863
Your Current Organism:
Anaerohalosphaera lusitana
NCBI taxonomy Id: 1936003
Other names: A. lusitana, Anaerohalosphaera lusitana Pradel et al., DSM 103484, JCM 31926, KCTC 15600, Phycisphaerae bacterium ST-NAGAB-D1, strain ST-NAGAB-D1
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