zraR_2 protein (Anaerohalosphaera lusitana) - STRING interaction network

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

zraR_2

Transcriptional regulatory protein ZraR. (490 aa)

Predicted Functional Partners:

rpoN1

0.791

AQT66931.1

0.565

cheA

0.555

fliG

0.552

cph1_2

0.536

luxQ_2

0.536

aas

0.534

fliS

0.513

AQT66891.1

0.500

pomA

0.496

Your Current Organism:

Anaerohalosphaera lusitana

NCBI taxonomy Id: 1936003
Other names: A. lusitana, Anaerohalosphaera lusitana Pradel et al., DSM 103484, JCM 31926, KCTC 15600, Phycisphaerae bacterium ST-NAGAB-D1, strain ST-NAGAB-D1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQT66891.1	AQT66931.1	STSP2_00029	STSP2_00069	Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.	Flagellar motor switch protein FliM.	0.935
AQT66891.1	cheA	STSP2_00029	STSP2_00017	Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.	Chemotaxis protein CheA.	0.833
AQT66891.1	cph1_2	STSP2_00029	STSP2_00173	Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.	Phytochrome-like protein cph1.	0.768
AQT66891.1	fliG	STSP2_00029	STSP2_00033	Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.	Flagellar motor switch protein FliG.	0.975
AQT66891.1	fliS	STSP2_00029	STSP2_00022	Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.	Flagellar protein FliS.	0.891
AQT66891.1	luxQ_2	STSP2_00029	STSP2_01345	Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.	Autoinducer 2 sensor kinase/phosphatase LuxQ.	0.768
AQT66891.1	pomA	STSP2_00029	STSP2_00038	Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.	Chemotaxis protein PomA.	0.957
AQT66891.1	zraR_2	STSP2_00029	STSP2_01318	Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.	Transcriptional regulatory protein ZraR.	0.500
AQT66931.1	AQT66891.1	STSP2_00069	STSP2_00029	Flagellar motor switch protein FliM.	Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.	0.935
AQT66931.1	cheA	STSP2_00069	STSP2_00017	Flagellar motor switch protein FliM.	Chemotaxis protein CheA.	0.895
AQT66931.1	cph1_2	STSP2_00069	STSP2_00173	Flagellar motor switch protein FliM.	Phytochrome-like protein cph1.	0.883
AQT66931.1	fliG	STSP2_00069	STSP2_00033	Flagellar motor switch protein FliM.	Flagellar motor switch protein FliG.	0.998
AQT66931.1	fliS	STSP2_00069	STSP2_00022	Flagellar motor switch protein FliM.	Flagellar protein FliS.	0.909
AQT66931.1	luxQ_2	STSP2_00069	STSP2_01345	Flagellar motor switch protein FliM.	Autoinducer 2 sensor kinase/phosphatase LuxQ.	0.883
AQT66931.1	pomA	STSP2_00069	STSP2_00038	Flagellar motor switch protein FliM.	Chemotaxis protein PomA.	0.867
AQT66931.1	zraR_2	STSP2_00069	STSP2_01318	Flagellar motor switch protein FliM.	Transcriptional regulatory protein ZraR.	0.565
aas	cph1_2	STSP2_01321	STSP2_00173	Bifunctional protein aas.	Phytochrome-like protein cph1.	0.514
aas	luxQ_2	STSP2_01321	STSP2_01345	Bifunctional protein aas.	Autoinducer 2 sensor kinase/phosphatase LuxQ.	0.514
aas	zraR_2	STSP2_01321	STSP2_01318	Bifunctional protein aas.	Transcriptional regulatory protein ZraR.	0.534
cheA	AQT66891.1	STSP2_00017	STSP2_00029	Chemotaxis protein CheA.	Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.	0.833

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Network Stats

number of nodes:

5

number of edges:

5

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

4

PPI enrichment p-value:

0.37

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

10 of 31

2.46

9.0

1.81e-20

GO:0019646

Aerobic electron transport chain

10 of 31

2.46

9.0

1.81e-20

GO:0006123

Mitochondrial electron transport, cytochrome c to oxygen

6 of 8

2.83

6.55

3.49e-13

GO:0006122

Mitochondrial electron transport, ubiquinol to cytochrome c

4 of 8

2.65

3.67

1.22e-07

GO:1902600

Proton transmembrane transport

6 of 115

1.67

2.48

3.61e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

8 of 43

2.22

5.83

7.07e-14

GO:0009055

Electron transfer activity

8 of 61

2.07

5.12

4.62e-13

GO:0008121

Ubiquinol-cytochrome-c reductase activity

4 of 7

2.71

3.95

3.80e-08

GO:0015078

Proton transmembrane transporter activity

8 of 112

1.81

3.82

3.05e-11

GO:0004129

Cytochrome-c oxidase activity

4 of 9

2.6

3.76

7.54e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070069

Cytochrome complex

10 of 16

2.75

11.18

2.02e-23

GO:0005746

Mitochondrial respirasome

10 of 41

2.34

8.52

1.61e-20

GO:0070469

Respirasome

11 of 59

2.22

8.41

4.17e-22

GO:0098803

Respiratory chain complex

10 of 44

2.31

8.33

2.27e-20

GO:0005751

Mitochondrial respiratory chain complex IV

6 of 6

2.95

7.23

2.52e-14

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10594

Cytochrome complex, and Peptidase M16, N-terminal

10 of 20

2.65

10.42

2.41e-22

CL:10598

Mitochondrial respiratory chain complex IV, and Mitochondrial electron transport, ubiquinol to cytochrome c

8 of 11

2.81

9.27

7.56e-19

CL:10502

Respiratory electron transport, and NmrA-like domain

11 of 68

2.16

7.8

3.68e-21

CL:10600

Mitochondrial respiratory chain complex IV

5 of 5

2.95

5.86

1.20e-11

CL:10624

Peptidase M16, zinc-binding site, and Mitochondrial respiratory chain complex III

2 of 5

2.55

1.49

0.0018

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

11 of 141

1.85

5.44

1.20e-18

map01100

Metabolic pathways

11 of 2872

0.54

0.46

9.73e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-611105

Respiratory electron transport

11 of 67

2.17

7.85

3.36e-21

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

11 of 80

2.09

7.29

1.02e-20

MAP-9707564

Cytoprotection by HMOX1

6 of 27

2.3

4.81

9.23e-11

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

11 of 181

1.74

4.62

3.52e-17

MAP-5628897

TP53 Regulates Metabolic Genes

6 of 35

2.19

4.42

2.99e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070069

Cytochrome complex

8 of 14

2.71

8.4

2.27e-17

GOCC:0005746

Mitochondrial respirasome

8 of 24

2.48

7.37

3.73e-16

GOCC:0098803

Respiratory chain complex

8 of 27

2.42

7.17

5.56e-16

GOCC:0005751

Mitochondrial respiratory chain complex IV

5 of 10

2.65

5.11

1.55e-10

GOCC:0098800

Inner mitochondrial membrane protein complex

8 of 77

1.97

4.76

6.73e-13

(more ...)

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