AQT68286.1 protein (Anaerohalosphaera lusitana)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:

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[Homology]

Score

AQT68286.1

Aspartate kinase. (143 aa)

Predicted Functional Partners:

AQT68288.1

0.929

AQT68289.1

0.916

AQT68287.1

0.894

AQT68283.1

0.755

putP_2

0.588

AQT68282.1

0.580

putP_1

0.508

AQT68290.1

0.503

AQT68291.1

0.503

AQT70228.1

0.434

Your Current Organism:

Anaerohalosphaera lusitana

NCBI taxonomy Id: 1936003
Other names: A. lusitana, Anaerohalosphaera lusitana Pradel et al., DSM 103484, JCM 31926, KCTC 15600, Phycisphaerae bacterium ST-NAGAB-D1, strain ST-NAGAB-D1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQT68282.1	AQT68283.1	STSP2_01440	STSP2_01441	ACT domain-containing protein.	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	0.891
AQT68282.1	AQT68286.1	STSP2_01440	STSP2_01444	ACT domain-containing protein.	Aspartate kinase.	0.580
AQT68282.1	AQT68287.1	STSP2_01440	STSP2_01445	ACT domain-containing protein.	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	0.773
AQT68282.1	AQT68288.1	STSP2_01440	STSP2_01446	ACT domain-containing protein.	Indolepyruvate oxidoreductase subunit beta.	0.827
AQT68282.1	AQT68289.1	STSP2_01440	STSP2_01447	ACT domain-containing protein.	2-oxoacid ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	0.813
AQT68282.1	putP_1	STSP2_01440	STSP2_01442	ACT domain-containing protein.	Propionate transporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.771
AQT68282.1	putP_2	STSP2_01440	STSP2_03432	ACT domain-containing protein.	Proline permease; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.557
AQT68283.1	AQT68282.1	STSP2_01441	STSP2_01440	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	ACT domain-containing protein.	0.891
AQT68283.1	AQT68286.1	STSP2_01441	STSP2_01444	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	Aspartate kinase.	0.755
AQT68283.1	AQT68287.1	STSP2_01441	STSP2_01445	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	0.950
AQT68283.1	AQT68288.1	STSP2_01441	STSP2_01446	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	Indolepyruvate oxidoreductase subunit beta.	0.620
AQT68283.1	AQT68289.1	STSP2_01441	STSP2_01447	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	2-oxoacid ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	0.651
AQT68283.1	putP_1	STSP2_01441	STSP2_01442	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	Propionate transporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.777
AQT68286.1	AQT68282.1	STSP2_01444	STSP2_01440	Aspartate kinase.	ACT domain-containing protein.	0.580
AQT68286.1	AQT68283.1	STSP2_01444	STSP2_01441	Aspartate kinase.	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	0.755
AQT68286.1	AQT68287.1	STSP2_01444	STSP2_01445	Aspartate kinase.	Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	0.894
AQT68286.1	AQT68288.1	STSP2_01444	STSP2_01446	Aspartate kinase.	Indolepyruvate oxidoreductase subunit beta.	0.929
AQT68286.1	AQT68289.1	STSP2_01444	STSP2_01447	Aspartate kinase.	2-oxoacid ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	0.916
AQT68286.1	AQT68290.1	STSP2_01444	STSP2_01448	Aspartate kinase.	Hypothetical protein.	0.503
AQT68286.1	AQT68291.1	STSP2_01444	STSP2_01449	Aspartate kinase.	Hypothetical protein.	0.503

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.32e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

7 of 25

2.0

3.95

5.53e-10

GO:0006352

DNA-templated transcription, initiation

3 of 15

1.85

1.41

0.0014

GO:0019438

Aromatic compound biosynthetic process

8 of 270

1.02

1.06

1.90e-05

GO:0018130

Heterocycle biosynthetic process

8 of 294

0.98

0.99

3.13e-05

GO:1901362

Organic cyclic compound biosynthetic process

8 of 305

0.97

0.96

3.63e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 6

2.37

2.73

5.59e-06

GO:0016987

Sigma factor activity

3 of 15

1.85

1.33

0.0021

GO:0003677

DNA binding

7 of 307

0.91

0.75

0.0010

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

4 of 9

2.2

2.71

3.94e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37075846

(2023) Transcription regulation by CarD in mycobacteria is guided by basal promoter kinetics.

4 of 6

2.37

2.55

1.31e-05

PMID:38741736

(2024) Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus.

3 of 3

2.55

2.0

0.00020

PMID:30200857

(2018) Transcriptional Responses to ppGpp and DksA.

4 of 14

2.0

1.99

9.46e-05

PMID:34254822

(2021) Promoter Architecture Differences among Alphaproteobacteria and Other Bacterial Taxa.

3 of 5

2.33

1.84

0.00034

PMID:24516534

(2014) Transcriptional profiling of nitrogen fixation and the role of NifA in the diazotrophic endophyte Azoarcus sp. strain BH72.

4 of 23

1.79

1.67

0.00027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:215

RNA polymerase, and Transcription termination

3 of 5

2.33

1.63

0.00087

CL:92

Ribosome, and RNA polymerase

4 of 67

1.32

0.8

0.0141

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsp03020

RNA polymerase

4 of 4

2.55

3.46

2.66e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 66

1.57

2.47

6.05e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

4 of 9

2.2

2.63

5.88e-06

KW-0731

Sigma factor

3 of 15

1.85

1.51

0.00081

KW-0804

Transcription

7 of 150

1.22

1.43

5.88e-06

KW-0548

Nucleotidyltransferase

4 of 45

1.5

1.36

0.00055

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

3 of 7

2.18

1.52

0.0013

PF04542

Sigma-70 region 2

3 of 11

1.98

1.39

0.0019

PF00140

Sigma-70 factor, region 1.2

2 of 2

2.55

1.12

0.0091

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000943

RNA polymerase sigma-70

3 of 4

2.42

1.62

0.00096

IPR007630

RNA polymerase sigma-70 region 4

3 of 7

2.18

1.47

0.0016

IPR014284

RNA polymerase sigma-70 like domain

3 of 11

1.98

1.28

0.0033

IPR013325

RNA polymerase sigma factor, region 2

3 of 11

1.98

1.28

0.0033

IPR007627

RNA polymerase sigma-70 region 2

3 of 11

1.98

1.28

0.0033

(more ...)

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