AQT69108.1 protein (Anaerohalosphaera lusitana)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AQT69108.1

Hypothetical protein. (868 aa)

Predicted Functional Partners:

AQT68203.1

0.746

AQT68964.1

0.695

AQT69763.1

0.683

abn2

0.653

apu_2

0.614

AQT68185.1

0.588

apu_1

0.564

AQT69808.1

0.560

AQT66993.1

0.559

xynD

0.550

Your Current Organism:

Anaerohalosphaera lusitana

NCBI taxonomy Id: 1936003
Other names: A. lusitana, Anaerohalosphaera lusitana Pradel et al., DSM 103484, JCM 31926, KCTC 15600, Phycisphaerae bacterium ST-NAGAB-D1, strain ST-NAGAB-D1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQT66993.1	AQT68203.1	STSP2_00131	STSP2_01358	Outer membrane assembly lipoprotein YfgL.	Hypothetical protein.	0.570
AQT66993.1	AQT69108.1	STSP2_00131	STSP2_02295	Outer membrane assembly lipoprotein YfgL.	Hypothetical protein.	0.559
AQT66993.1	AQT69763.1	STSP2_00131	STSP2_02960	Outer membrane assembly lipoprotein YfgL.	Hypothetical protein.	0.413
AQT66993.1	apu_1	STSP2_00131	STSP2_00260	Outer membrane assembly lipoprotein YfgL.	Alpha-amylase/pullulanase.	0.403
AQT68185.1	AQT68203.1	STSP2_01340	STSP2_01358	Immunoglobulin I-set domain protein.	Hypothetical protein.	0.590
AQT68185.1	AQT68964.1	STSP2_01340	STSP2_02141	Immunoglobulin I-set domain protein.	PEP-CTERM protein-sorting domain-containing protein.	0.410
AQT68185.1	AQT69108.1	STSP2_01340	STSP2_02295	Immunoglobulin I-set domain protein.	Hypothetical protein.	0.588
AQT68185.1	apu_1	STSP2_01340	STSP2_00260	Immunoglobulin I-set domain protein.	Alpha-amylase/pullulanase.	0.667
AQT68185.1	apu_2	STSP2_01340	STSP2_00262	Immunoglobulin I-set domain protein.	Alpha-amylase/pullulanase.	0.633
AQT68203.1	AQT66993.1	STSP2_01358	STSP2_00131	Hypothetical protein.	Outer membrane assembly lipoprotein YfgL.	0.570
AQT68203.1	AQT68185.1	STSP2_01358	STSP2_01340	Hypothetical protein.	Immunoglobulin I-set domain protein.	0.590
AQT68203.1	AQT68964.1	STSP2_01358	STSP2_02141	Hypothetical protein.	PEP-CTERM protein-sorting domain-containing protein.	0.739
AQT68203.1	AQT69108.1	STSP2_01358	STSP2_02295	Hypothetical protein.	Hypothetical protein.	0.746
AQT68203.1	AQT69763.1	STSP2_01358	STSP2_02960	Hypothetical protein.	Hypothetical protein.	0.407
AQT68203.1	AQT69808.1	STSP2_01358	STSP2_03005	Hypothetical protein.	Hypothetical protein.	0.559
AQT68964.1	AQT68185.1	STSP2_02141	STSP2_01340	PEP-CTERM protein-sorting domain-containing protein.	Immunoglobulin I-set domain protein.	0.410
AQT68964.1	AQT68203.1	STSP2_02141	STSP2_01358	PEP-CTERM protein-sorting domain-containing protein.	Hypothetical protein.	0.739
AQT68964.1	AQT69108.1	STSP2_02141	STSP2_02295	PEP-CTERM protein-sorting domain-containing protein.	Hypothetical protein.	0.695
AQT68964.1	AQT69808.1	STSP2_02141	STSP2_03005	PEP-CTERM protein-sorting domain-containing protein.	Hypothetical protein.	0.574
AQT68964.1	apu_1	STSP2_02141	STSP2_00260	PEP-CTERM protein-sorting domain-containing protein.	Alpha-amylase/pullulanase.	0.583

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

10

average node degree:

4

avg. local clustering coefficient:

1

expected number of edges:

4

PPI enrichment p-value:

0.00543

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

7 of 83

1.39

1.75

3.73e-06

GO:0000160

Phosphorelay signal transduction system

6 of 75

1.36

1.55

2.55e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2251

PAS domain, and Nucleotide cyclase

9 of 17

2.18

6.3

1.30e-15

CL:2254

PAS-associated, C-terminal, and Nucleotide cyclase

6 of 10

2.24

4.69

9.94e-11

CL:2232

Signal transduction response regulator, receiver domain, and Histidine kinase-like ATPases

11 of 74

1.63

3.89

1.30e-15

CL:2257

PAC motif

4 of 5

2.36

3.3

3.60e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

8 of 283

0.91

0.87

6.68e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

10 of 61

1.68

3.89

3.62e-14

KW-0418

Kinase

7 of 101

1.3

1.67

1.33e-06

KW-0902

Two-component regulatory system

2 of 12

1.68

0.74

0.0345

KW-0067

ATP-binding

6 of 245

0.85

0.62

0.0053

KW-0238

DNA-binding

4 of 139

0.92

0.52

0.0345

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001789

Signal transduction response regulator, receiver domain

10 of 52

1.74

4.15

5.38e-14

IPR011006

CheY-like superfamily

10 of 55

1.72

4.05

5.38e-14

IPR001610

PAC motif

5 of 6

2.38

4.0

1.17e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 26

1.89

3.65

9.43e-10

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 27

1.87

3.61

9.43e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

10 of 52

1.74

4.34

4.32e-15

SM00388

His Kinase A (phosphoacceptor) domain

7 of 29

1.84

3.71

2.21e-10

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

5 of 11

2.12

3.61

1.99e-08

SM00387

Histidine kinase-like ATPases

7 of 34

1.77

3.46

3.95e-10

SM00091

PAS domain

5 of 16

1.96

3.16

7.35e-08

(more ...)

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