SNAP23 protein (Athene cunicularia) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

SNAP23

Synaptosomal-associated protein 23. (209 aa)

Predicted Functional Partners:

VAMP3

0.997

VAMP4

0.995

ENSACUP00000000639

0.989

VAMP1

0.989

STX2

0.976

STX1A

0.976

VAMP7

0.970

STX11

0.962

NAPB

0.955

RIMS2

0.947

Your Current Organism:

Athene cunicularia

NCBI taxonomy Id: 194338
Other names: A. cunicularia, Speotyto cunicularia, burrowing owl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACUP00000000639	NAPB	ENSACUP00000000639	ENSACUP00000014128	Vesicle-associated membrane protein 2-like.	Beta-soluble NSF attachment protein.	0.948
ENSACUP00000000639	RIMS2	ENSACUP00000000639	ENSACUP00000018851	Vesicle-associated membrane protein 2-like.	Regulating synaptic membrane exocytosis 2.	0.871
ENSACUP00000000639	SNAP23	ENSACUP00000000639	ENSACUP00000000466	Vesicle-associated membrane protein 2-like.	Synaptosomal-associated protein 23.	0.989
ENSACUP00000000639	STX11	ENSACUP00000000639	ENSACUP00000013715	Vesicle-associated membrane protein 2-like.	Syntaxin 11.	0.798
ENSACUP00000000639	STX1A	ENSACUP00000000639	ENSACUP00000014923	Vesicle-associated membrane protein 2-like.	Syntaxin-1A isoform X1.	0.986
ENSACUP00000000639	STX2	ENSACUP00000000639	ENSACUP00000010260	Vesicle-associated membrane protein 2-like.	Syntaxin 1B/2/3.	0.986
ENSACUP00000000639	VAMP1	ENSACUP00000000639	ENSACUP00000002964	Vesicle-associated membrane protein 2-like.	Vesicle-associated membrane protein 1 isoform X1.	0.901
ENSACUP00000000639	VAMP3	ENSACUP00000000639	ENSACUP00000005428	Vesicle-associated membrane protein 2-like.	Vesicle-associated membrane protein 3 isoform X1.	0.986
ENSACUP00000000639	VAMP4	ENSACUP00000000639	ENSACUP00000002307	Vesicle-associated membrane protein 2-like.	Vesicle-associated membrane protein 4.	0.882
ENSACUP00000000639	VAMP7	ENSACUP00000000639	ENSACUP00000008622	Vesicle-associated membrane protein 2-like.	Vesicle-associated membrane protein 7.	0.797
NAPB	ENSACUP00000000639	ENSACUP00000014128	ENSACUP00000000639	Beta-soluble NSF attachment protein.	Vesicle-associated membrane protein 2-like.	0.948
NAPB	SNAP23	ENSACUP00000014128	ENSACUP00000000466	Beta-soluble NSF attachment protein.	Synaptosomal-associated protein 23.	0.955
NAPB	STX11	ENSACUP00000014128	ENSACUP00000013715	Beta-soluble NSF attachment protein.	Syntaxin 11.	0.961
NAPB	STX1A	ENSACUP00000014128	ENSACUP00000014923	Beta-soluble NSF attachment protein.	Syntaxin-1A isoform X1.	0.948
NAPB	STX2	ENSACUP00000014128	ENSACUP00000010260	Beta-soluble NSF attachment protein.	Syntaxin 1B/2/3.	0.948
NAPB	VAMP1	ENSACUP00000014128	ENSACUP00000002964	Beta-soluble NSF attachment protein.	Vesicle-associated membrane protein 1 isoform X1.	0.948
NAPB	VAMP3	ENSACUP00000014128	ENSACUP00000005428	Beta-soluble NSF attachment protein.	Vesicle-associated membrane protein 3 isoform X1.	0.971
NAPB	VAMP4	ENSACUP00000014128	ENSACUP00000002307	Beta-soluble NSF attachment protein.	Vesicle-associated membrane protein 4.	0.956
NAPB	VAMP7	ENSACUP00000014128	ENSACUP00000008622	Beta-soluble NSF attachment protein.	Vesicle-associated membrane protein 7.	0.949
RIMS2	ENSACUP00000000639	ENSACUP00000018851	ENSACUP00000000639	Regulating synaptic membrane exocytosis 2.	Vesicle-associated membrane protein 2-like.	0.871

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.837

expected number of edges:

15

PPI enrichment p-value:

9.99e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

8 of 50

1.58

2.71

5.27e-09

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005506

Iron ion binding

5 of 18

1.82

2.45

2.53e-06

GO:0009055

Electron transfer activity

5 of 26

1.66

2.07

9.43e-06

GO:0008137

NADH dehydrogenase (ubiquinone) activity

3 of 8

1.95

1.61

0.00059

GO:0051536

Iron-sulfur cluster binding

8 of 111

1.24

1.56

1.06e-06

GO:0008901

Ferredoxin hydrogenase activity

2 of 2

2.38

1.36

0.0030

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045272

Plasma membrane respiratory chain complex I

2 of 2

2.38

1.12

0.0088

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1644

Mixed, incl. Rubredoxin, and 3Fe-4S ferredoxin

5 of 5

2.38

3.66

6.26e-08

CL:980

Oxidative phosphorylation

5 of 17

1.85

2.51

2.13e-06

CL:983

Iron hydrogenase, and Respirasome

4 of 8

2.08

2.43

1.15e-05

CL:940

Mixed, incl. Citrate cycle (TCA cycle), and Oxidative phosphorylation

6 of 73

1.3

1.45

2.80e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

5 of 30

1.6

1.94

1.38e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045271

Respiratory chain complex I

4 of 8

2.08

2.35

1.71e-05

GOCC:0045272

Plasma membrane respiratory chain complex I

2 of 6

1.9

0.97

0.0135

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0408

Iron

4 of 45

1.33

0.93

0.0057

KW-0411

Iron-sulfur

3 of 35

1.31

0.65

0.0379

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01257

Thioredoxin-like [2Fe-2S] ferredoxin

3 of 3

2.38

1.88

0.00029

PF00037

4Fe-4S binding domain

4 of 16

1.78

1.65

0.00029

PF13510

2Fe-2S iron-sulfur cluster binding domain

2 of 2

2.38

1.04

0.0121

PF02906

Iron only hydrogenase large subunit, C-terminal domain

2 of 5

1.98

0.8

0.0315

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017896

4Fe-4S ferredoxin-type, iron-sulphur binding domain

6 of 34

1.63

2.13

3.71e-06

IPR017900

4Fe-4S ferredoxin, iron-sulphur binding, conserved site

5 of 30

1.6

1.73

6.90e-05

IPR036249

Thioredoxin-like superfamily

3 of 12

1.78

1.04

0.0083

IPR036991

Iron hydrogenase, small subunit superfamily

2 of 2

2.38

0.88

0.0248

IPR036010

2Fe-2S ferredoxin-like superfamily

2 of 2

2.38

0.88

0.0248

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00929

NADH-ubiquinone oxidoreductase-G iron-sulfur binding region

2 of 2

2.38

1.11

0.0092

SM00902

Iron hydrogenase small subunit

2 of 2

2.38

1.11

0.0092

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