STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)    
Predicted Functional Partners:
ilvN
Acetolactate synthase, small subunit; Identified by similarity to GP:5733116; match to protein family HMM PF01842; match to protein family HMM TIGR00119.
 
 
 0.998
ilvB
Acetolactate synthase, large subunit; Identified by similarity to EGAD:156267; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118.
 
 
 0.998
ilvD
Dihydroxy-acid dehydratase; Identified by similarity to SP:P51785; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family.
 
 
 0.997
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
 
  
 0.984
CT0614
3-isopropylmalate dehydratase, large subunit, putative; Identified by match to protein family HMM PF00330; match to protein family HMM TIGR01343; match to protein family HMM TIGR02086; Belongs to the aconitase/IPM isomerase family.
  
 0.983
CT0613
3-isopropylmalate dehydratase, small subunit, putative; Identified by match to protein family HMM PF00694; match to protein family HMM TIGR02087; Belongs to the LeuD family.
 
  
 0.958
gltB
Glutamate synthase, large subunit; Identified by similarity to EGAD:109137; similarity to EGAD:134205; match to protein family HMM PF01493; match to protein family HMM PF01645; match to protein family HMM PF04897; match to protein family HMM PF04898.
  
  
 0.788
leuA-1
2-isopropylmalate synthase; Identified by similarity to EGAD:32071; match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
  
 0.780
nifV
Homocitrate synthase; Identified by similarity to EGAD:10481; match to protein family HMM PF00682; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
  
 0.724
thrC
Threonine synthase; Identified by similarity to EGAD:7615; similarity to EGAD:16850; match to protein family HMM PF00291; match to protein family HMM TIGR00260.
  
  
 0.699
Your Current Organism:
Chlorobaculum tepidum
NCBI taxonomy Id: 194439
Other names: C. tepidum TLS, Chlorobaculum tepidum TLS, Chlorobium tepidum TLS
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.