node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dgoK | ilvD | SAMCFNEI73_Ch0859 | SAMCFNEI73_Ch0856 | 2-dehydro-3-deoxygalactonokinase; Region:COG3734G. | Dihydroxy-acid dehydratase IlvD; Region:COG0129EG; Belongs to the IlvD/Edd family. | 0.694 |
gltB-2 | ilvA | SAMCFNEI73_Ch3243 | SAMCFNEI73_Ch1774 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.646 |
gltB-2 | ilvB | SAMCFNEI73_Ch3243 | SAMCFNEI73_Ch0559 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | Acetolactate synthase isozyme 1 large subunit IlvB; Region:COG0028EH; Belongs to the TPP enzyme family. | 0.584 |
gltB-2 | ilvC | SAMCFNEI73_Ch3243 | SAMCFNEI73_Ch2351 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.776 |
gltB-2 | ilvD | SAMCFNEI73_Ch3243 | SAMCFNEI73_Ch0856 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | Dihydroxy-acid dehydratase IlvD; Region:COG0129EG; Belongs to the IlvD/Edd family. | 0.880 |
gltB-2 | ilvH | SAMCFNEI73_Ch3243 | SAMCFNEI73_Ch2391 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | Acetolactate synthase small subunit IlvH; Region:COG0440E. | 0.580 |
gltB-2 | ilvI | SAMCFNEI73_Ch3243 | SAMCFNEI73_Ch2392 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | Acetolactate synthase isozyme 3 large subunit IlvI; Region:COG0028EH. | 0.584 |
gltB-2 | leuB | SAMCFNEI73_Ch3243 | SAMCFNEI73_Ch3696 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.643 |
gltB-2 | leuC | SAMCFNEI73_Ch3243 | SAMCFNEI73_Ch3588 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.734 |
gltB-2 | leuD | SAMCFNEI73_Ch3243 | SAMCFNEI73_Ch3570 | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.583 |
ilvA | gltB-2 | SAMCFNEI73_Ch1774 | SAMCFNEI73_Ch3243 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | 0.646 |
ilvA | ilvB | SAMCFNEI73_Ch1774 | SAMCFNEI73_Ch0559 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase isozyme 1 large subunit IlvB; Region:COG0028EH; Belongs to the TPP enzyme family. | 0.943 |
ilvA | ilvC | SAMCFNEI73_Ch1774 | SAMCFNEI73_Ch2351 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.667 |
ilvA | ilvD | SAMCFNEI73_Ch1774 | SAMCFNEI73_Ch0856 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Dihydroxy-acid dehydratase IlvD; Region:COG0129EG; Belongs to the IlvD/Edd family. | 0.684 |
ilvA | ilvH | SAMCFNEI73_Ch1774 | SAMCFNEI73_Ch2391 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase small subunit IlvH; Region:COG0440E. | 0.969 |
ilvA | ilvI | SAMCFNEI73_Ch1774 | SAMCFNEI73_Ch2392 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase isozyme 3 large subunit IlvI; Region:COG0028EH. | 0.949 |
ilvA | leuB | SAMCFNEI73_Ch1774 | SAMCFNEI73_Ch3696 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.949 |
ilvA | leuC | SAMCFNEI73_Ch1774 | SAMCFNEI73_Ch3588 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.548 |
ilvA | leuD | SAMCFNEI73_Ch1774 | SAMCFNEI73_Ch3570 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.558 |
ilvB | gltB-2 | SAMCFNEI73_Ch0559 | SAMCFNEI73_Ch3243 | Acetolactate synthase isozyme 1 large subunit IlvB; Region:COG0028EH; Belongs to the TPP enzyme family. | Ferredoxin-dependent glutamate synthase 1; Region:COG0067E. | 0.584 |