STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysGSiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (485 aa)    
Predicted Functional Partners:
sir
Sulfite reductase [ferredoxin] 2; Region:COG0155P.
 
  
 0.987
cobA
uroporphyrinogen-III C-methyltransferase CobA; Region:COG0007H; Belongs to the precorrin methyltransferase family.
 
 
0.967
hemD
uroporphyrinogen-III synthase protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.957
cysH
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite.
 
  
 0.956
cobI
Precorrin-2 C(20)-methyltransferase CobI; Region:COG2243H; Belongs to the precorrin methyltransferase family.
 
 
 0.956
hemC
Porphobilinogen deaminase HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.950
hemE
Uroporphyrinogen decarboxylase HemE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.950
cysD
Sulfate adenylyltransferase subunit 2; Region:COG0175EH.
 
  
 0.922
APG90899.1
Hypothetical protein.
 
  
 0.919
cobG
precorrin-3B synthase CobG; Region:COG0155P.
  
  
 0.911
Your Current Organism:
Sinorhizobium americanum
NCBI taxonomy Id: 194963
Other names: ATCC BAA-532, CIP 108390, DSM 15007, Ensifer americanum, Ensifer americanus, Ensifer americanus corrig. (Toledo et al. 2003) Wang et al. 2015, Ensifer sp. AC14c, Ensifer sp. CFNEI 156, S. americanum, Sinorhizobium americanum Toledo et al. 2004, Sinorhizobium americanus, Sinorhizobium sp. CFNEI 156, Sinorhizobium sp. CFNEI 54, strain CFNEI 156
Server load: medium (64%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.