STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APG91097.1Site-specific recombinase, phage integrase family; Region:COG0582LX. (444 aa)    
Predicted Functional Partners:
APG92256.1
Competence protein F; Region:COG1040R.
   
    0.580
tyrC
Cyclohexadienyl dehydrogenase; Region:COG0287E.
  
    0.529
APG90487.1
Prophage protein; Region:COG2135O; Belongs to the SOS response-associated peptidase family.
   
  
 0.509
gpt
Xanthine phosphoribosyltransferase Gpt; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
   
    0.465
apt
Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
    0.465
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.454
pleC
Non-motile and phage-resistance protein PleC; Region:COG0591E.
  
  
 0.452
APG89897.1
Erythronolide synthase, modules 3 and 4; Region:COG0236IQ.
  
 
 0.446
topA
DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.430
Your Current Organism:
Sinorhizobium americanum
NCBI taxonomy Id: 194963
Other names: ATCC BAA-532, CIP 108390, DSM 15007, Ensifer americanum, Ensifer americanus, Ensifer americanus corrig. (Toledo et al. 2003) Wang et al. 2015, Ensifer sp. AC14c, Ensifer sp. CFNEI 156, S. americanum, Sinorhizobium americanum Toledo et al. 2004, Sinorhizobium americanus, Sinorhizobium sp. CFNEI 156, Sinorhizobium sp. CFNEI 54, strain CFNEI 156
Server load: medium (72%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.