| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobB | cobD | SAMCFNEI73_Ch2188 | SAMCFNEI73_Ch2186 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.976 |
| cobB | cobE | SAMCFNEI73_Ch2188 | SAMCFNEI73_Ch2190 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | CobE protein CobE. | 0.901 |
| cobB | cobF | SAMCFNEI73_Ch2188 | SAMCFNEI73_Ch3354 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-6A synthase; Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | 0.716 |
| cobB | cobH | SAMCFNEI73_Ch2188 | SAMCFNEI73_Ch3352 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-8X methylmutase CobH; Region:COG2082H. | 0.995 |
| cobB | cobI | SAMCFNEI73_Ch2188 | SAMCFNEI73_Ch3351 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-2 C(20)-methyltransferase CobI; Region:COG2243H; Belongs to the precorrin methyltransferase family. | 0.889 |
| cobB | cobJ | SAMCFNEI73_Ch2188 | SAMCFNEI73_Ch3350 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-3B C(17)-methyltransferase CobJ; Region:COG1010H. | 0.889 |
| cobB | cobK | SAMCFNEI73_Ch2188 | SAMCFNEI73_Ch3349 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-6A reductase CobK; Region:COG2099H. | 0.873 |
| cobB | cobL | SAMCFNEI73_Ch2188 | SAMCFNEI73_Ch3348 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-6Y C(5,15)-methyltransferase; Region:COG2241H. | 0.923 |
| cobB | cobM | SAMCFNEI73_Ch2188 | SAMCFNEI73_Ch3347 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-4 C(11)-methyltransferase CobM; Region:COG2875H; Belongs to the precorrin methyltransferase family. | 0.924 |
| cobB | cobQ | SAMCFNEI73_Ch2188 | SAMCFNEI73_Ch2200 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.964 |
| cobD | cobB | SAMCFNEI73_Ch2186 | SAMCFNEI73_Ch2188 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.976 |
| cobD | cobE | SAMCFNEI73_Ch2186 | SAMCFNEI73_Ch2190 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | CobE protein CobE. | 0.774 |
| cobD | cobH | SAMCFNEI73_Ch2186 | SAMCFNEI73_Ch3352 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | precorrin-8X methylmutase CobH; Region:COG2082H. | 0.887 |
| cobD | cobI | SAMCFNEI73_Ch2186 | SAMCFNEI73_Ch3351 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-2 C(20)-methyltransferase CobI; Region:COG2243H; Belongs to the precorrin methyltransferase family. | 0.685 |
| cobD | cobJ | SAMCFNEI73_Ch2186 | SAMCFNEI73_Ch3350 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | precorrin-3B C(17)-methyltransferase CobJ; Region:COG1010H. | 0.833 |
| cobD | cobK | SAMCFNEI73_Ch2186 | SAMCFNEI73_Ch3349 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | precorrin-6A reductase CobK; Region:COG2099H. | 0.685 |
| cobD | cobL | SAMCFNEI73_Ch2186 | SAMCFNEI73_Ch3348 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | precorrin-6Y C(5,15)-methyltransferase; Region:COG2241H. | 0.856 |
| cobD | cobM | SAMCFNEI73_Ch2186 | SAMCFNEI73_Ch3347 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Precorrin-4 C(11)-methyltransferase CobM; Region:COG2875H; Belongs to the precorrin methyltransferase family. | 0.868 |
| cobD | cobQ | SAMCFNEI73_Ch2186 | SAMCFNEI73_Ch2200 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.988 |
| cobE | cobB | SAMCFNEI73_Ch2190 | SAMCFNEI73_Ch2188 | CobE protein CobE. | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.901 |