Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
metH-2Methionine synthase MetH; Region:COG1410E. (320 aa)    
Predicted Functional Partners:
metH
Methionine synthase MetH; Region:COG0646E.
 
 0.998
APG91506.1
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Region:COG0685E; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.988
mtbC
Dimethylamine corrinoid protein; Region:COG5012C.
  
 0.980
metF
5,10-methylenetetrahydrofolate reductase; Region:COG0685E; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.979
metH-3
Methionine synthase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
 
0.953
APG90668.1
O-acetylhomoserine aminocarboxypropyltransferase; Region:COG2873E.
  
 
 0.921
ahcY
S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
    
 0.920
metK
S-adenosylmethionine synthase MetK; Region:COG0192H; Belongs to the AdoMet synthase family.
    
 0.920
metZ
O-succinylhomoserine sulfhydrylase MetZ; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
  
 
 0.919
metC
Cystathionine beta-lyase MetC; Region:COG0626E.
  
 
 0.919
Your Current Organism:
Sinorhizobium americanum
NCBI taxonomy Id: 194963
Other names: ATCC BAA-532, CIP 108390, DSM 15007, Ensifer americanum, Ensifer americanus, Ensifer americanus corrig. (Toledo et al. 2003) Wang et al. 2015, Ensifer sp. AC14c, Ensifer sp. CFNEI 156, S. americanum, Sinorhizobium americanum Toledo et al. 2004, Sinorhizobium americanus, Sinorhizobium sp. CFNEI 156, Sinorhizobium sp. CFNEI 54, strain CFNEI 156
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