STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (587 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.986
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.986
ilvE
Branched-chain-amino-acid aminotransferase IlvE; Region:COG0115EH.
  
 0.973
ilvE-2
Branched-chain-amino-acid aminotransferase IlvE; Region:COG0115EH.
  
 0.973
ilvD-3
Dihydroxy-acid dehydratase IlvD; Region:COG0129EG; Belongs to the IlvD/Edd family.
  
 
 0.957
ilvH
Acetolactate synthase small subunit IlvH; Region:COG0440E.
 
 
 0.954
fadA
Acyltransferase; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.923
vraB
acetyl-CoA C-acetyltransferase VraB; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.923
atoB
acetyl-CoA acetyltransferase AtoB; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.923
phbA
acetyl-CoA acetyltransferase PhbA; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.923
Your Current Organism:
Sinorhizobium americanum
NCBI taxonomy Id: 194963
Other names: ATCC BAA-532, CIP 108390, DSM 15007, Ensifer americanum, Ensifer americanus, Ensifer americanus corrig. (Toledo et al. 2003) Wang et al. 2015, Ensifer sp. AC14c, Ensifer sp. CFNEI 156, S. americanum, Sinorhizobium americanum Toledo et al. 2004, Sinorhizobium americanus, Sinorhizobium sp. CFNEI 156, Sinorhizobium sp. CFNEI 54, strain CFNEI 156
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