Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mdeA-2Methionine gamma-lyase MdeA; Region:COG0626E. (390 aa)    
Predicted Functional Partners:
lutR
HTH-type transcriptional regulator LutR; Region:COG2186K.
 
     0.868
APG92154.1
Sugar ABC transporter sugar-binding protein; Region:COG1653G.
 
     0.750
cysK
Cysteine synthase A.
 
 
 0.691
metH-3
Methionine synthase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
  
 0.669
cysK-2
Cysteine synthase A; Region:COG0031E.
 
 
 0.663
rplL
50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.
    
   0.629
metF
5,10-methylenetetrahydrofolate reductase; Region:COG0685E; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.604
metA
Homoserine O-succinyltransferase MetA; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
 
  
 0.602
APG91506.1
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase; Region:COG0685E; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.579
puuB
Gamma-glutamylputrescine oxidoreductase PuuB; Region:COG0665E.
       0.525
Your Current Organism:
Sinorhizobium americanum
NCBI taxonomy Id: 194963
Other names: ATCC BAA-532, CIP 108390, DSM 15007, Ensifer americanum, Ensifer americanus, Ensifer americanus corrig. (Toledo et al. 2003) Wang et al. 2015, Ensifer sp. AC14c, Ensifer sp. CFNEI 156, S. americanum, Sinorhizobium americanum Toledo et al. 2004, Sinorhizobium americanus, Sinorhizobium sp. CFNEI 156, Sinorhizobium sp. CFNEI 54, strain CFNEI 156
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