acsA-2 protein (Sinorhizobium americanum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

acsA-2

Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa)

Predicted Functional Partners:

gltA

0.973

glcB

0.953

fadB-2

0.934

fadA

0.934

vraB

0.934

atoB

0.934

phbA

0.934

mmsA

0.929

acoD

0.929

ald-3

0.929

Your Current Organism:

Sinorhizobium americanum

NCBI taxonomy Id: 194963
Other names: ATCC BAA-532, CIP 108390, DSM 15007, Ensifer americanum, Ensifer americanus, Ensifer americanus corrig. (Toledo et al. 2003) Wang et al. 2015, Ensifer sp. AC14c, Ensifer sp. CFNEI 156, S. americanum, Sinorhizobium americanum Toledo et al. 2004, Sinorhizobium americanus, Sinorhizobium sp. CFNEI 156, Sinorhizobium sp. CFNEI 54, strain CFNEI 156

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acoD	acsA-2	SAMCFNEI73_Ch2649	SAMCFNEI73_Ch3712	Acetaldehyde dehydrogenase 2; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.929
acoD	ald-3	SAMCFNEI73_Ch2649	SAMCFNEI73_Ch2874	Acetaldehyde dehydrogenase 2; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	0.911
acoD	gltA	SAMCFNEI73_Ch2649	SAMCFNEI73_Ch1640	Acetaldehyde dehydrogenase 2; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	Citrate synthase GltA; Region:COG0372C; Belongs to the citrate synthase family.	0.414
acsA-2	acoD	SAMCFNEI73_Ch3712	SAMCFNEI73_Ch2649	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Acetaldehyde dehydrogenase 2; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	0.929
acsA-2	ald-3	SAMCFNEI73_Ch3712	SAMCFNEI73_Ch2874	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Aldehyde dehydrogenase; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	0.929
acsA-2	atoB	SAMCFNEI73_Ch3712	SAMCFNEI73_Ch3366	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	acetyl-CoA acetyltransferase AtoB; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.	0.934
acsA-2	fadA	SAMCFNEI73_Ch3712	SAMCFNEI73_Ch0526	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Acyltransferase; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.	0.934
acsA-2	fadB-2	SAMCFNEI73_Ch3712	SAMCFNEI73_Ch0525	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	3-hydroxyacyl-CoA dehydrogenase; Region:COG1024I.	0.934
acsA-2	glcB	SAMCFNEI73_Ch3712	SAMCFNEI73_Ch0062	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.	0.953
acsA-2	gltA	SAMCFNEI73_Ch3712	SAMCFNEI73_Ch1640	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Citrate synthase GltA; Region:COG0372C; Belongs to the citrate synthase family.	0.973
acsA-2	mmsA	SAMCFNEI73_Ch3712	SAMCFNEI73_Ch0755	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Methylmalonate-semialdehyde dehydrogenase; Region:COG1012C.	0.929
acsA-2	phbA	SAMCFNEI73_Ch3712	SAMCFNEI73_Ch3646	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	acetyl-CoA acetyltransferase PhbA; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.	0.934
acsA-2	vraB	SAMCFNEI73_Ch3712	SAMCFNEI73_Ch0934	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	acetyl-CoA C-acetyltransferase VraB; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.	0.934
ald-3	acoD	SAMCFNEI73_Ch2874	SAMCFNEI73_Ch2649	Aldehyde dehydrogenase; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	Acetaldehyde dehydrogenase 2; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	0.911
ald-3	acsA-2	SAMCFNEI73_Ch2874	SAMCFNEI73_Ch3712	Aldehyde dehydrogenase; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.929
ald-3	fadB-2	SAMCFNEI73_Ch2874	SAMCFNEI73_Ch0525	Aldehyde dehydrogenase; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	3-hydroxyacyl-CoA dehydrogenase; Region:COG1024I.	0.920
ald-3	gltA	SAMCFNEI73_Ch2874	SAMCFNEI73_Ch1640	Aldehyde dehydrogenase; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	Citrate synthase GltA; Region:COG0372C; Belongs to the citrate synthase family.	0.414
ald-3	mmsA	SAMCFNEI73_Ch2874	SAMCFNEI73_Ch0755	Aldehyde dehydrogenase; Region:COG1012C; Belongs to the aldehyde dehydrogenase family.	Methylmalonate-semialdehyde dehydrogenase; Region:COG1012C.	0.922
atoB	acsA-2	SAMCFNEI73_Ch3366	SAMCFNEI73_Ch3712	acetyl-CoA acetyltransferase AtoB; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.934
atoB	fadA	SAMCFNEI73_Ch3366	SAMCFNEI73_Ch0526	acetyl-CoA acetyltransferase AtoB; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.	Acyltransferase; Region:COG0183I; Belongs to the thiolase-like superfamily. Thiolase family.	0.843

page 1 of 5

Server load: medium (58%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About