glnM_2 protein (Campylobacter coli) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

glnM_2

Putative glutamine ABC transporter permease protein GlnM. (261 aa)

Predicted Functional Partners:

artP

0.982

fliY

0.981

glnQ_1

0.918

glnQ_2

0.915

glnQ_3

0.912

peb1A

0.751

glnP_1

0.612

glnP_2

0.601

glnM_1

0.567

ALU99440.1

0.536

Your Current Organism:

Campylobacter coli

NCBI taxonomy Id: 195
Other names: ATCC 33559, C. coli, CCUG 11283, CCUG 14540, CCUG:33450 [[Campylobacter hyoilei]], CIP 70.80, CIP 7080, Campylobacter hyoilei, Campylobacter sp. OH-18-18281-4B, Campylobacter sp. OH-18-7816, DSM 4689, JCM 2529, LMG 6440, LMG 9860, LMG:6440, LMG:9860, NCTC 11366, Vibrio coli, strain RMIT 32A [[Campylobacter hyoilei]]

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALU99440.1	glnM_2	ATE51_01834	ATE51_01832	Hypothetical protein.	Putative glutamine ABC transporter permease protein GlnM.	0.536
artP	glnM_1	ATE51_02154	ATE51_01710	Arginine-binding extracellular protein ArtP precursor; Belongs to the bacterial solute-binding protein 3 family.	Putative glutamine ABC transporter permease protein GlnM.	0.981
artP	glnM_2	ATE51_02154	ATE51_01832	Arginine-binding extracellular protein ArtP precursor; Belongs to the bacterial solute-binding protein 3 family.	Putative glutamine ABC transporter permease protein GlnM.	0.982
artP	glnP_1	ATE51_02154	ATE51_01712	Arginine-binding extracellular protein ArtP precursor; Belongs to the bacterial solute-binding protein 3 family.	Putative glutamine ABC transporter permease protein GlnP.	0.981
artP	glnP_2	ATE51_02154	ATE51_03278	Arginine-binding extracellular protein ArtP precursor; Belongs to the bacterial solute-binding protein 3 family.	Putative glutamine ABC transporter permease protein GlnP.	0.955
artP	glnQ_1	ATE51_02154	ATE51_01706	Arginine-binding extracellular protein ArtP precursor; Belongs to the bacterial solute-binding protein 3 family.	Glutamine transport ATP-binding protein GlnQ.	0.821
artP	glnQ_2	ATE51_02154	ATE51_01742	Arginine-binding extracellular protein ArtP precursor; Belongs to the bacterial solute-binding protein 3 family.	Glutamine transport ATP-binding protein GlnQ.	0.835
artP	glnQ_3	ATE51_02154	ATE51_03276	Arginine-binding extracellular protein ArtP precursor; Belongs to the bacterial solute-binding protein 3 family.	Glutamine transport ATP-binding protein GlnQ.	0.825
fliY	glnM_1	ATE51_02006	ATE51_01710	Cystine-binding periplasmic protein precursor.	Putative glutamine ABC transporter permease protein GlnM.	0.980
fliY	glnM_2	ATE51_02006	ATE51_01832	Cystine-binding periplasmic protein precursor.	Putative glutamine ABC transporter permease protein GlnM.	0.981
fliY	glnP_1	ATE51_02006	ATE51_01712	Cystine-binding periplasmic protein precursor.	Putative glutamine ABC transporter permease protein GlnP.	0.945
fliY	glnP_2	ATE51_02006	ATE51_03278	Cystine-binding periplasmic protein precursor.	Putative glutamine ABC transporter permease protein GlnP.	0.952
fliY	glnQ_1	ATE51_02006	ATE51_01706	Cystine-binding periplasmic protein precursor.	Glutamine transport ATP-binding protein GlnQ.	0.761
fliY	glnQ_2	ATE51_02006	ATE51_01742	Cystine-binding periplasmic protein precursor.	Glutamine transport ATP-binding protein GlnQ.	0.788
fliY	glnQ_3	ATE51_02006	ATE51_03276	Cystine-binding periplasmic protein precursor.	Glutamine transport ATP-binding protein GlnQ.	0.762
glnM_1	artP	ATE51_01710	ATE51_02154	Putative glutamine ABC transporter permease protein GlnM.	Arginine-binding extracellular protein ArtP precursor; Belongs to the bacterial solute-binding protein 3 family.	0.981
glnM_1	fliY	ATE51_01710	ATE51_02006	Putative glutamine ABC transporter permease protein GlnM.	Cystine-binding periplasmic protein precursor.	0.980
glnM_1	glnM_2	ATE51_01710	ATE51_01832	Putative glutamine ABC transporter permease protein GlnM.	Putative glutamine ABC transporter permease protein GlnM.	0.567
glnM_1	glnP_1	ATE51_01710	ATE51_01712	Putative glutamine ABC transporter permease protein GlnM.	Putative glutamine ABC transporter permease protein GlnP.	0.993
glnM_1	glnP_2	ATE51_01710	ATE51_03278	Putative glutamine ABC transporter permease protein GlnM.	Putative glutamine ABC transporter permease protein GlnP.	0.502

page 1 of 4

Network Stats

number of nodes:

9

number of edges:

26

average node degree:

5.78

avg. local clustering coefficient:

0.871

expected number of edges:

8

PPI enrichment p-value:

3.62e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005975

Carbohydrate metabolic process

7 of 424

1.13

1.07

0.00025

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

6 of 115

1.63

2.2

2.21e-06

GO:0008061

Chitin binding

3 of 12

2.31

1.95

0.00020

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

7 of 289

1.29

1.64

1.83e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8890

Mixed, incl. Streptogrisin prodomain, and Polysaccharide catabolic process

10 of 35

2.37

8.4

7.76e-20

CL:8892

Mixed, incl. Glycoside hydrolase family 18, catalytic domain, and Coagulation factor 5/8 C-terminal domain, discoidin domain

8 of 27

2.38

6.88

1.52e-15

CL:8895

Mixed, incl. Glycoside hydrolase family 18, catalytic domain, and Cellulose/chitin-binding protein, N-terminal

5 of 16

2.41

4.19

4.91e-09

CL:8896

Glycoside hydrolase family 18, catalytic domain, and Cellulose/chitin-binding protein, N-terminal

4 of 11

2.47

3.35

3.75e-07

CL:8932

Mixed, incl. Streptogrisin prodomain, and Glucosidase activity

3 of 7

2.54

2.4

3.33e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005576

Extracellular region

7 of 386

1.17

1.26

2.92e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

4 of 73

1.65

1.64

0.00018

KW-0732

Signal

9 of 818

0.95

1.01

5.04e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00704

Glycosyl hydrolases family 18

3 of 4

2.79

2.36

4.65e-05

PF02018

Carbohydrate binding domain

2 of 3

2.73

1.2

0.0066

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001223

Glycoside hydrolase family 18, catalytic domain

4 of 11

2.47

2.84

4.04e-06

IPR011583

Chitinase II

3 of 9

2.43

1.94

0.00024

IPR001579

Glycosyl hydrolases family 18 (GH18) active site

3 of 10

2.39

1.93

0.00024

IPR008979

Galactose-binding-like domain superfamily

4 of 42

1.89

1.75

0.00024

IPR003961

Fibronectin type III

3 of 18

2.13

1.59

0.00088

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00060

Fibronectin type 3 domain

3 of 19

2.11

1.75

0.00040

SM00458

Ricin-type beta-trefoil

2 of 9

2.26

1.15

0.0071

SM00231

Coagulation factor 5/8 C-terminal domain, discoidin domain

2 of 13

2.1

1.08

0.0090

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