| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCO0139 | glyA | ATE51_00170 | ATE51_03410 | Aspartate racemase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
| CCO0139 | metA | ATE51_00170 | ATE51_04402 | Aspartate racemase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.800 |
| CCO0139 | pcs | ATE51_00170 | ATE51_01372 | Aspartate racemase. | Phosphatidylcholine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| CCO0139 | tdcB | ATE51_00170 | ATE51_01986 | Aspartate racemase. | L-threonine dehydratase catabolic TdcB. | 0.900 |
| CCO0139 | tdcG | ATE51_00170 | ATE51_00280 | Aspartate racemase. | L-serine dehydratase TdcG; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.900 |
| CCO0139 | trpB | ATE51_00170 | ATE51_03516 | Aspartate racemase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| glyA | CCO0139 | ATE51_03410 | ATE51_00170 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aspartate racemase. | 0.900 |
| glyA | metA | ATE51_03410 | ATE51_04402 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.800 |
| glyA | metF | ATE51_03410 | ATE51_01202 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.940 |
| glyA | pcs | ATE51_03410 | ATE51_01372 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphatidylcholine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.904 |
| glyA | tdcB | ATE51_03410 | ATE51_01986 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-threonine dehydratase catabolic TdcB. | 0.920 |
| glyA | tdcG | ATE51_03410 | ATE51_00280 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase TdcG; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.961 |
| glyA | trpB | ATE51_03410 | ATE51_03516 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.920 |
| hom | mdeA | ATE51_03952 | ATE51_04408 | Homoserine dehydrogenase. | Methionine gamma-lyase. | 0.859 |
| hom | metA | ATE51_03952 | ATE51_04402 | Homoserine dehydrogenase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.947 |
| hom | metF | ATE51_03952 | ATE51_01202 | Homoserine dehydrogenase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.610 |
| hom | tdcG | ATE51_03952 | ATE51_00280 | Homoserine dehydrogenase. | L-serine dehydratase TdcG; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.803 |
| hom | thrB | ATE51_03952 | ATE51_04194 | Homoserine dehydrogenase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.997 |
| mdeA | hom | ATE51_04408 | ATE51_03952 | Methionine gamma-lyase. | Homoserine dehydrogenase. | 0.859 |
| mdeA | metA | ATE51_04408 | ATE51_04402 | Methionine gamma-lyase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.988 |
