node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPE1429 | clsD | gene:10490693 | gene:10490694 | Conserved hypothetical protein; 513 aa, similar to gp:AP001516_278 GTP pyrophosphokinase from Bacillus halodurans (211 aa); 30.2% identity in 139 aa overlap. | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. | 0.553 |
clsD | CPE1429 | gene:10490694 | gene:10490693 | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. | Conserved hypothetical protein; 513 aa, similar to gp:AP001516_278 GTP pyrophosphokinase from Bacillus halodurans (211 aa); 30.2% identity in 139 aa overlap. | 0.553 |
clsD | comEC | gene:10490694 | gene:10490763 | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. | 291 aa, similar to pir:T44344 late competence protein homolog comEC from Bacillus halodurans (266 aa); 33.7% identity in 246 aa overlap; CPE1499. | 0.425 |
clsD | comEC-2 | gene:10490694 | gene:10490921 | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. | 284 aa, similar to pir:T44344 late competence protein homolog comEC from Bacillus halodurans (266 aa); 33.5% identity in 242 aa overlap. Putative N-terminal signal sequence was found by PSORT; CPE1657. | 0.442 |
clsD | plc | gene:10490694 | gene:10489266 | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. | Phospholipase C; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes. | 0.900 |
clsD | psdD | gene:10490694 | gene:10489257 | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. | Probable phosphatidylserine decarboxylase precursor; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.715 |
comEC | clsD | gene:10490763 | gene:10490694 | 291 aa, similar to pir:T44344 late competence protein homolog comEC from Bacillus halodurans (266 aa); 33.7% identity in 246 aa overlap; CPE1499. | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. | 0.425 |
comEC-2 | clsD | gene:10490921 | gene:10490694 | 284 aa, similar to pir:T44344 late competence protein homolog comEC from Bacillus halodurans (266 aa); 33.5% identity in 242 aa overlap. Putative N-terminal signal sequence was found by PSORT; CPE1657. | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. | 0.442 |
plc | clsD | gene:10489266 | gene:10490694 | Phospholipase C; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes. | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. | 0.900 |
plc | psdD | gene:10489266 | gene:10489257 | Phospholipase C; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes. | Probable phosphatidylserine decarboxylase precursor; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.900 |
psdD | clsD | gene:10489257 | gene:10490694 | Probable phosphatidylserine decarboxylase precursor; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. | 0.715 |
psdD | plc | gene:10489257 | gene:10489266 | Probable phosphatidylserine decarboxylase precursor; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | Phospholipase C; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes. | 0.900 |