STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CPE2432Conserved hypothetical protein; Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation. (354 aa)    
Predicted Functional Partners:
radA
DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.959
nagB
Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
       0.615
CPE2435
Probable transcriptional regulator; 240 aa, similar to pir:D70044 transcription regulator GntR family homolog yvoA from Bacillus subtilis (243 aa); 37.3% identity in 225 aa overlap; GntR family.
       0.615
ctsR
Transcriptional repressor of class III stress genes; 151 aa, similar to gp:AB031211_4 CtsR from Bacillus halodurans (156 aa); 38.3% identity in 149 aa overlap; CPE2444; Belongs to the CtsR family.
  
  
 0.502
CPE2442
Probable creatine kinase; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family.
  
    0.494
CPE2443
Conserved hypothetical protein; 199 aa, similar to gp:LMU40604_2 Listeria monocytogenes ClpC ATPase (mec) gene, complete cds from Listeria monocytogenes (174 aa); 34% identity in 162 aa overlap.
  
    0.492
CPE1739
Probable protein phosphatase 1; 239 aa, similar to gpu:AP001515_239 BH2505 gene product from Bacillus halodurans (249 aa); 40.6% identity in 229 aa overlap.
      
 0.459
clpC
ClpC adenosine triphosphatase; 814 aa, similar to sp:CLPC_BACSU NEGATIVE REGULATOR OF GENETIC COMPETENCE CLPC/MECB from Bacillus subtilis (810 aa); 53.1% identity in 813 aa overlap; CPE2441; Belongs to the ClpA/ClpB family.
  
  
 0.455
CPE2430
Conserved hypothetical protein; 368 aa, similar to gpu:AP001507_106 BH0106 gene product from Bacillus halodurans (362 aa); 47.7% identity in 367 aa overlap. Putative N-terminal signal sequence and 3 putative transmembrane regions were found by PSORT.
  
  
 0.433
CPE0302
Hypothetical protein; 426 aa, no significant homology. Putative N-terminal signal sequence and 7 putative transmembrane regions were found by PSORT.
  
     0.432
Your Current Organism:
Clostridium perfringens 13
NCBI taxonomy Id: 195102
Other names: C. perfringens str. 13, Clostridium perfringens str. 13
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