Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CPF_0106Putative thiazole biosynthesis protein ThiH; Identified by match to protein family HMM PF04055; match to protein family HMM PF06968. (473 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.980
CPF_0103
Identified by match to protein family HMM PF01926; match to protein family HMM PF08477; match to protein family HMM TIGR00231.
  
 0.926
thiH
Thiazole biosynthesis protein ThiH; Identified by similarity to SP:P30140; match to protein family HMM PF04055; match to protein family HMM PF06968; match to protein family HMM TIGR02351.
  
  
 
0.916
CPF_0107
Conserved hypothetical protein; Identified by similarity to GB:CAC39225.1.
 
     0.878
CPF_1076
[Fe] hydrogenase; Identified by match to protein family HMM PF00037; match to protein family HMM PF00301; match to protein family HMM PF02256; match to protein family HMM PF02906; match to protein family HMM PF02915; match to protein family HMM TIGR02512.
 
   
 0.824
hydA
Iron hydrogenase; Identified by similarity to GB:BAD29951.1; match to protein family HMM PF00037; match to protein family HMM PF00111; match to protein family HMM PF02256; match to protein family HMM PF02906; match to protein family HMM TIGR02512.
 
   
 0.762
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.712
CPF_2900
[Fe] hydrogenase; Identified by match to protein family HMM PF00037; match to protein family HMM PF02906.
 
   
 0.698
CPF_0270
[Fe] hydrogenase; Identified by match to protein family HMM PF00037; match to protein family HMM PF02906.
 
   
 0.677
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.673
Your Current Organism:
Clostridium perfringens ATCC 13124
NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124
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