Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CPF_0126Identified by match to protein family HMM PF03595. (338 aa)    
Predicted Functional Partners:
CPF_2364
Conserved hypothetical protein; Identified by similarity to GB:AAO36386.1; match to protein family HMM PF07550.
  
     0.722
pfo
Perfringolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
  
   
 0.716
CPF_1182
Putative membrane protein; Identified by similarity to SP:P58769; match to protein family HMM PF01794.
  
     0.693
CPF_1102
Putative membrane protein; Identified by similarity to GB:AAO35944.1; match to protein family HMM PF01794.
  
     0.684
CPF_1189
Pentapeptide repeat protein; Identified by match to protein family HMM PF00805.
  
     0.663
CPF_1226
Putative membrane protein.
  
     0.648
CPF_2367
Major facilitator family transporter; Identified by match to protein family HMM PF07690.
 
     0.622
hdc
Histidine decarboxylase, pyruvoyl type; Identified by match to protein family HMM PF02329; match to protein family HMM TIGR00541.
  
     0.613
CPF_0981
Conserved hypothetical protein; Identified by similarity to GB:CAA15293.1.
  
     0.594
colA
Microbial collagenase; Identified by similarity to SP:P43153; match to protein family HMM PF00801; match to protein family HMM PF01752; match to protein family HMM PF04151; match to protein family HMM PF08453.
  
     0.592
Your Current Organism:
Clostridium perfringens ATCC 13124
NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124
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