STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfoPerfringolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity). (500 aa)    
Predicted Functional Partners:
colA
Microbial collagenase; Identified by similarity to SP:P43153; match to protein family HMM PF00801; match to protein family HMM PF01752; match to protein family HMM PF04151; match to protein family HMM PF08453.
  
  
 0.774
CPF_2364
Conserved hypothetical protein; Identified by similarity to GB:AAO36386.1; match to protein family HMM PF07550.
 
  
 0.759
CPF_2367
Major facilitator family transporter; Identified by match to protein family HMM PF07690.
 
    0.758
CPF_0981
Conserved hypothetical protein; Identified by similarity to GB:CAA15293.1.
  
   
 0.736
CPF_0126
Identified by match to protein family HMM PF03595.
  
     0.716
CPF_1182
Putative membrane protein; Identified by similarity to SP:P58769; match to protein family HMM PF01794.
  
    0.661
CPF_2336
Putative membrane protein.
  
    0.631
CPF_0742
Conserved hypothetical protein; Identified by similarity to GB:CAJ70527.1.
  
     0.619
CPF_1102
Putative membrane protein; Identified by similarity to GB:AAO35944.1; match to protein family HMM PF01794.
  
    0.619
plc
Phospholipase C; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes.
   
  
 0.609
Your Current Organism:
Clostridium perfringens ATCC 13124
NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124
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