Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CPF_0495Conserved hypothetical protein; Identified by similarity to GB:BAC14481.1; match to protein family HMM TIGR01167. (232 aa)    
Predicted Functional Partners:
CPF_0497
Von Willebrand factor type A domain protein; Identified by match to protein family HMM PF00092.
 
    0.917
CPF_0494
Hypothetical protein; Identified by glimmer; putative.
 
     0.915
CPF_0496
Conserved hypothetical protein; Identified by similarity to GB:BAB80221.1.
       0.716
sipW
Signal peptidase I; Identified by match to protein family HMM PF00717; match to protein family HMM TIGR02228.
 
     0.672
CPF_1576
Phage tail tape measure protein, TP901 family; Identified by match to protein family HMM TIGR01760.
 
     0.630
CPF_1087
Identified by match to protein family HMM PF00128; match to protein family HMM PF02368; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF07523; match to protein family HMM TIGR01167; match to protein family HMM TIGR02104; Belongs to the glycosyl hydrolase 13 family.
     
 0.565
CPF_1583
Phage protein, QlrG family; Identified by match to protein family HMM TIGR01560.
   
 
 0.564
CPF_2609
Glycosyl hydrolase, family 1; Identified by match to protein family HMM PF00232; Belongs to the glycosyl hydrolase 1 family.
   
 
 0.556
colA
Microbial collagenase; Identified by similarity to SP:P43153; match to protein family HMM PF00801; match to protein family HMM PF01752; match to protein family HMM PF04151; match to protein family HMM PF08453.
 
  
 0.532
pfo
Perfringolysin O; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
 
     0.524
Your Current Organism:
Clostridium perfringens ATCC 13124
NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.