Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
manAMannose-6-phosphate isomerase, class I; Identified by similarity to SP:Q59935; match to protein family HMM PF01238; match to protein family HMM TIGR00218. (325 aa)    
Predicted Functional Partners:
CPF_0818
PTS system, mannose/fructose/sorbose family, IIB component; Identified by match to protein family HMM PF03610; match to protein family HMM PF03830; match to protein family HMM TIGR00824.
 
  
 0.948
pgi
Glucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family.
 
 
 0.947
pfkA-2
Phosphofructokinase family protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
    
 0.935
glmS
Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
    
 0.928
CPF_0819
PTS system, mannose/fructose/sorbose family, IIC component; Identified by match to protein family HMM PF03609.
 
  
  0.925
nagB
Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
     
 0.925
CPF_0820
PTS system, mannose/fructose/sorbose family, IID component; Identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828.
 
  
  0.921
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
     
 0.911
CPF_1717
PTS system, IIA component; Identified by match to protein family HMM PF03610.
    
 0.911
CPF_2965
PTS system, IIA component; Identified by match to protein family HMM PF03610.
    
 0.911
Your Current Organism:
Clostridium perfringens ATCC 13124
NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124
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