node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPF_1670 | fhs | CPF_1670 | CPF_2785 | Identified by match to protein family HMM PF02574. | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.926 |
CPF_1670 | fmt | CPF_1670 | CPF_1005 | Identified by match to protein family HMM PF02574. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.907 |
CPF_1670 | folA | CPF_1670 | CPF_0051 | Identified by match to protein family HMM PF02574. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.912 |
CPF_1670 | glyA | CPF_1670 | CPF_2184 | Identified by match to protein family HMM PF02574. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
CPF_1670 | luxS | CPF_1670 | CPF_0171 | Identified by match to protein family HMM PF02574. | Autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.924 |
CPF_1670 | metC | CPF_1670 | CPF_0169 | Identified by match to protein family HMM PF02574. | Cystathionine beta-lyase; Identified by similarity to GB:AAF14695.1; match to protein family HMM PF01053. | 0.965 |
CPF_1670 | metG-2 | CPF_1670 | CPF_2847 | Identified by match to protein family HMM PF02574. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.911 |
CPF_1670 | metK | CPF_1670 | CPF_2435 | Identified by match to protein family HMM PF02574. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.931 |
CPF_1670 | purH | CPF_1670 | CPF_0677 | Identified by match to protein family HMM PF02574. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.915 |
CPF_1670 | purN | CPF_1670 | CPF_0676 | Identified by match to protein family HMM PF02574. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.925 |
fhs | CPF_1670 | CPF_2785 | CPF_1670 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Identified by match to protein family HMM PF02574. | 0.926 |
fhs | folA | CPF_2785 | CPF_0051 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.919 |
fhs | glyA | CPF_2785 | CPF_2184 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
fhs | purH | CPF_2785 | CPF_0677 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.975 |
fhs | purN | CPF_2785 | CPF_0676 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.966 |
fmt | CPF_1670 | CPF_1005 | CPF_1670 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Identified by match to protein family HMM PF02574. | 0.907 |
fmt | folA | CPF_1005 | CPF_0051 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.915 |
fmt | glyA | CPF_1005 | CPF_2184 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |
fmt | metG-2 | CPF_1005 | CPF_2847 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.934 |
fmt | purN | CPF_1005 | CPF_0676 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.936 |