gmk protein (Clostridium perfringens ATCC 13124)

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Score

gmk

Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (216 aa)

Predicted Functional Partners:

rpoZ

0.981

guaA

0.959

xpt

0.939

xpt-2

0.939

CPF_2002

0.939

apt

0.938

ndk

0.924

relA

0.921

hpt2

0.914

hpt1

0.914

Your Current Organism:

Clostridium perfringens ATCC 13124

NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPF_2002	gmk	CPF_2002	CPF_2001	Conserved hypothetical protein; Identified by similarity to SP:Q97ID1; match to protein family HMM PF04025; Belongs to the RemA family.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.939
CPF_2002	rpoZ	CPF_2002	CPF_2000	Conserved hypothetical protein; Identified by similarity to SP:Q97ID1; match to protein family HMM PF04025; Belongs to the RemA family.	DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.856
apt	gmk	CPF_2194	CPF_2001	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.938
apt	guaA	CPF_2194	CPF_2557	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.979
apt	hpt1	CPF_2194	CPF_2787	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37472; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.921
apt	hpt2	CPF_2194	CPF_2216	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37472; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.921
apt	relA	CPF_2194	CPF_2193	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.640
apt	xpt	CPF_2194	CPF_0319	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.953
apt	xpt-2	CPF_2194	CPF_1498	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.933
gmk	CPF_2002	CPF_2001	CPF_2002	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Conserved hypothetical protein; Identified by similarity to SP:Q97ID1; match to protein family HMM PF04025; Belongs to the RemA family.	0.939
gmk	apt	CPF_2001	CPF_2194	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.938
gmk	guaA	CPF_2001	CPF_2557	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.959
gmk	hpt1	CPF_2001	CPF_2787	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37472; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.914
gmk	hpt2	CPF_2001	CPF_2216	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypoxanthine phosphoribosyltransferase; Identified by similarity to SP:P37472; match to protein family HMM PF00156; match to protein family HMM TIGR01203; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.914
gmk	ndk	CPF_2001	CPF_2227	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.924
gmk	relA	CPF_2001	CPF_2193	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.921
gmk	rpoZ	CPF_2001	CPF_2000	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.981
gmk	xpt	CPF_2001	CPF_0319	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.939
gmk	xpt-2	CPF_2001	CPF_1498	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.	0.939
guaA	apt	CPF_2557	CPF_2194	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.979