node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPF_2195 | CPF_2198 | CPF_2195 | CPF_2198 | DHH domain protein; Identified by match to protein family HMM PF01368. | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | 0.510 |
CPF_2195 | apt | CPF_2195 | CPF_2194 | DHH domain protein; Identified by match to protein family HMM PF01368. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.742 |
CPF_2195 | dtd | CPF_2195 | CPF_2192 | DHH domain protein; Identified by match to protein family HMM PF01368. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.556 |
CPF_2195 | hisS | CPF_2195 | CPF_2189 | DHH domain protein; Identified by match to protein family HMM PF01368. | histidyl-tRNA synthetase; Identified by similarity to SP:O32422; match to protein family HMM PF00587; match to protein family HMM PF03129; match to protein family HMM TIGR00442. | 0.557 |
CPF_2195 | priA | CPF_2195 | CPF_1998 | DHH domain protein; Identified by match to protein family HMM PF01368. | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.500 |
CPF_2195 | queA | CPF_2195 | CPF_2202 | DHH domain protein; Identified by match to protein family HMM PF01368. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.509 |
CPF_2195 | relA | CPF_2195 | CPF_2193 | DHH domain protein; Identified by match to protein family HMM PF01368. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.579 |
CPF_2195 | ruvB | CPF_2195 | CPF_2203 | DHH domain protein; Identified by match to protein family HMM PF01368. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.506 |
CPF_2195 | secD | CPF_2195 | CPF_2197 | DHH domain protein; Identified by match to protein family HMM PF01368. | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.627 |
CPF_2195 | secF | CPF_2195 | CPF_2196 | DHH domain protein; Identified by match to protein family HMM PF01368. | Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.604 |
CPF_2198 | CPF_2195 | CPF_2198 | CPF_2195 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | DHH domain protein; Identified by match to protein family HMM PF01368. | 0.510 |
CPF_2198 | apt | CPF_2198 | CPF_2194 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.481 |
CPF_2198 | dtd | CPF_2198 | CPF_2192 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.429 |
CPF_2198 | queA | CPF_2198 | CPF_2202 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.514 |
CPF_2198 | relA | CPF_2198 | CPF_2193 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.431 |
CPF_2198 | ruvB | CPF_2198 | CPF_2203 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.474 |
CPF_2198 | secD | CPF_2198 | CPF_2197 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.704 |
CPF_2198 | secF | CPF_2198 | CPF_2196 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.716 |
apt | CPF_2195 | CPF_2194 | CPF_2195 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | DHH domain protein; Identified by match to protein family HMM PF01368. | 0.742 |
apt | CPF_2198 | CPF_2194 | CPF_2198 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | 0.481 |