Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spoVACStage V sporulation protein AC; Identified by match to protein family HMM PF03862; match to protein family HMM TIGR02838. (155 aa)    
Predicted Functional Partners:
spoVAD
Stage V sporulation protein AD; Identified by similarity to SP:P40869; match to protein family HMM PF07451; match to protein family HMM TIGR02845.
 
  
 0.989
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
   
 0.914
sigF
RNA polymerase sigma-F factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
     0.897
spoVAE
Stage V sporulation protein AE; Identified by match to protein family HMM PF03862; match to protein family HMM TIGR02839.
 
  
0.886
gpr
Spore protease; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.
  
  
 0.866
spoVAF
Spore germination protein AF; Identified by similarity to SP:P31845; match to protein family HMM PF03323.
 
  
 0.855
spoIIAA
Anti-sigma F factor antagonist; Identified by match to protein family HMM PF01740; match to protein family HMM TIGR00377; match to protein family HMM TIGR02886; Belongs to the anti-sigma-factor antagonist family.
 
   
 0.844
spoIVA
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.811
CPF_2068
Stage IV sporulation protein B; Identified by match to protein family HMM PF05580; match to protein family HMM TIGR02860.
 
   
 0.809
spoIIID
Stage III sporulation protein D; Identified by similarity to SP:P15281; match to protein family HMM TIGR02844.
  
   
 0.806
Your Current Organism:
Clostridium perfringens ATCC 13124
NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124
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