node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPF_0671 | fhs | CPF_0671 | CPF_2785 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.971 |
CPF_0671 | folD | CPF_0671 | CPF_2077 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.864 |
CPF_0671 | glyA | CPF_0671 | CPF_2184 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.982 |
CPF_0671 | purC | CPF_0671 | CPF_0673 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by similarity to SP:P12046; match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family. | 0.999 |
CPF_0671 | purH | CPF_0671 | CPF_0677 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.999 |
CPF_0671 | purN | CPF_0671 | CPF_0676 | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
CPF_1670 | fhs | CPF_1670 | CPF_2785 | Identified by match to protein family HMM PF02574. | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.926 |
CPF_1670 | folA | CPF_1670 | CPF_0051 | Identified by match to protein family HMM PF02574. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.912 |
CPF_1670 | glyA | CPF_1670 | CPF_2184 | Identified by match to protein family HMM PF02574. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
CPF_1670 | purH | CPF_1670 | CPF_0677 | Identified by match to protein family HMM PF02574. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.915 |
CPF_1670 | purN | CPF_1670 | CPF_0676 | Identified by match to protein family HMM PF02574. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.925 |
CPF_1670 | thyX | CPF_1670 | CPF_2735 | Identified by match to protein family HMM PF02574. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.903 |
CPF_2123 | fhs | CPF_2123 | CPF_2785 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.973 |
CPF_2123 | folD | CPF_2123 | CPF_2077 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | folD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.966 |
CPF_2123 | purH | CPF_2123 | CPF_0677 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Identified by similarity to SP:P12048; match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.906 |
CPF_2123 | purN | CPF_2123 | CPF_0676 | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.911 |
fhs | CPF_0671 | CPF_2785 | CPF_0671 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine synthase; Identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857. | 0.971 |
fhs | CPF_1670 | CPF_2785 | CPF_1670 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Identified by match to protein family HMM PF02574. | 0.926 |
fhs | CPF_2123 | CPF_2785 | CPF_2123 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Identified by match to protein family HMM PF04961. | 0.973 |
fhs | folA | CPF_2785 | CPF_0051 | Formate--tetrahydrofolate ligase; Identified by similarity to SP:P13419; match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.919 |