Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
spoIIEStage II sporulation protein E; Identified by similarity to SP:P37475; match to protein family HMM PF07228; match to protein family HMM TIGR02865. (796 aa)    
Predicted Functional Partners:
spoIIGA
Sporulation factor SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
  
  
 0.941
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.873
CPF_2297
Stage II sporulation protein P; Identified by match to protein family HMM PF07454; match to protein family HMM TIGR02867.
  
   
 0.863
CPF_2475
Stage II sporulation protein R; Identified by similarity to SP:P39151; match to protein family HMM PF09551; match to protein family HMM TIGR02837.
  
   
 0.861
spoIIID
Stage III sporulation protein D; Identified by similarity to SP:P15281; match to protein family HMM TIGR02844.
  
   
 0.854
spo0A
Spo0A protein; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
  
 0.840
sigG
RNA polymerase sigma-G factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.839
spoVT
Stage V sprulation protein T; Identified by similarity to SP:P37554; match to protein family HMM PF04014; match to protein family HMM TIGR01439; match to protein family HMM TIGR02851.
 
   
 0.836
spoIVA
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.827
CPF_2087
Stage III sporulation protein AA; Identified by match to protein family HMM TIGR02858.
  
   
 0.819
Your Current Organism:
Clostridium perfringens ATCC 13124
NCBI taxonomy Id: 195103
Other names: C. perfringens ATCC 13124, Clostridium perfringens str. ATCC 13124, Clostridium perfringens strain ATCC 13124
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