STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BD01_0182Dehydrogenases (flavoproteins); Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (395 aa)    
Predicted Functional Partners:
BD01_2040
4-hydroxybenzoate polyprenyltransferase-related prenyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
 
 
 0.963
carS
CDP-diglyceride synthetase; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.
     
 0.911
BD01_0183
Ferredoxin; COG1145.
 
     0.844
BD01_0184
Putative transcriptional regulators; COG1777.
     
 0.823
BD01_0185
Thiol-disulfide isomerase and thioredoxins; COG0526.
       0.672
BD01_2062
NADPH-dependent glutamate synthase beta chain-related oxidoreductase; COG0493.
       0.577
BD01_1965
Phytoene dehydrogenase-related protein; COG1233.
 
  
 0.513
BD01_2232
Geranylgeranyl pyrophosphate synthase; COG0142; Belongs to the FPP/GGPP synthase family.
 
 
 0.506
nusA
Transcription elongation factor; Participates in transcription termination. Belongs to the NusA family.
 
    0.449
BD01_1880
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); COG1143.
 
  
 0.417
Your Current Organism:
Thermococcus nautili
NCBI taxonomy Id: 195522
Other names: CNCM 4275, JCM 19601, T. nautili, Thermococcus nautili Gorlas et al. 2014, Thermococcus nautilus, Thermococcus sp. 30-1, strain 30-1
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