STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BD01_0646Mn2+-dependent serine/threonine protein kinase; COG3642. (222 aa)    
Predicted Functional Partners:
kae1
(SSU ribosomal protein S18P)-alanine acetyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
   
 0.964
BD01_0647
Hypothetical protein.
       0.819
BD01_1615
Hypothetical protein; COG1617.
    
 
 0.772
BD01_0648
Chaperonin GroEL (HSP60 family); COG0459; Belongs to the TCP-1 chaperonin family.
 
  
 0.747
rps15
Ribosomal protein S15P.
 
   
 0.639
rps24e
Ribosomal protein S24E (rps24E); Belongs to the eukaryotic ribosomal protein eS24 family.
 
    0.589
infB
Translation initiation factor 2 (IF-2, GTPase); Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
 
  
 0.502
htpX
Zn-dependent protease with chaperone function; COG0501; Belongs to the peptidase M48B family.
       0.493
rps2
Ribosomal protein S2P (rps2P); Belongs to the universal ribosomal protein uS2 family.
 
  
 0.485
map
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
 
  
 0.483
Your Current Organism:
Thermococcus nautili
NCBI taxonomy Id: 195522
Other names: CNCM 4275, JCM 19601, T. nautili, Thermococcus nautili Gorlas et al. 2014, Thermococcus nautilus, Thermococcus sp. 30-1, strain 30-1
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