STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BD01_0651Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); COG1028. (267 aa)    
Predicted Functional Partners:
hcp
6Fe-6S prismane cluster-containing protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
  
 
 0.782
mre11
DNA repair exonuclease; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
 
 
 0.714
BD01_0652
NADPH-dependent glutamate synthase beta chain-related oxidoreductase; COG0493.
 
   
 0.631
dys
Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
     
 0.631
BD01_0722
Serine/threonine protein kinase; COG0515.
  
 0.614
BD01_0724
Serine/threonine protein kinase; COG0515.
  
 0.614
BD01_0389
NADH:ubiquinone oxidoreductase 49 kD subunit 7; COG0649; Belongs to the complex I 49 kDa subunit family.
  
 
 0.578
BD01_0390
NADH:ubiquinone oxidoreductase 27 kD subunit; COG0852.
   
 
 0.578
gap
Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; COG0057.
 
 
 0.572
BD01_0391
NADH:ubiquinone oxidoreductase 20 kD subunit-related Fe-S oxidoreductase; COG0377; Belongs to the complex I 20 kDa subunit family.
  
 
 0.571
Your Current Organism:
Thermococcus nautili
NCBI taxonomy Id: 195522
Other names: CNCM 4275, JCM 19601, T. nautili, Thermococcus nautili Gorlas et al. 2014, Thermococcus nautilus, Thermococcus sp. 30-1, strain 30-1
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