STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fniL-lactate dehydrogenase (FMN-dependent)-related alpha-hydroxy acid dehydrogenase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (372 aa)    
Predicted Functional Partners:
BD01_2232
Geranylgeranyl pyrophosphate synthase; COG0142; Belongs to the FPP/GGPP synthase family.
  
 
 0.981
BD01_2227
Putative archaeal kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
 
  
  0.948
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
  
 0.837
BD01_2230
Hypothetical protein.
       0.785
rnj
Putative hydrolase of the metallo-beta-lactamase superfamily; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
  
    0.725
BD01_1730
3-hydroxy-3-methylglutaryl CoA synthase; COG3425; Belongs to the thiolase-like superfamily. UPF0219 family.
 
  
 0.704
BD01_0308
Hydroxymethylglutaryl-CoA reductase; COG1257; Belongs to the HMG-CoA reductase family.
 
   
 0.675
hcp
6Fe-6S prismane cluster-containing protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
  
 
 0.648
rpl40e
Ribosomal protein L40E (rpl40E); Belongs to the eukaryotic ribosomal protein eL40 family.
   
 
 0.644
BD01_2055
Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase; COG0075.
  
 0.597
Your Current Organism:
Thermococcus nautili
NCBI taxonomy Id: 195522
Other names: CNCM 4275, JCM 19601, T. nautili, Thermococcus nautili Gorlas et al. 2014, Thermococcus nautilus, Thermococcus sp. 30-1, strain 30-1
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