A0A482WPY3 protein (Laodelphax striatellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

A0A482WPY3

J domain-containing protein. (244 aa)

Predicted Functional Partners:

A0A482WHJ7

0.834

A0A482X968

0.834

A0A482XIX8

0.834

A0A482WQ21

0.746

A0A482WXS7

0.745

A0A482X1J8

0.744

A0A482WFA2

0.719

hsc70

0.708

A0A482WRI4

0.708

A0A482WSU1

0.708

Your Current Organism:

Laodelphax striatellus

NCBI taxonomy Id: 195883
Other names: L. striatellus, Laodelphax striatella, small brown planthopper

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A482WFA2	A0A482WHJ7	A0A482WFA2	A0A482WHJ7	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.897
A0A482WFA2	A0A482WPY3	A0A482WFA2	A0A482WPY3	ANK_REP_REGION domain-containing protein.	J domain-containing protein.	0.719
A0A482WFA2	A0A482WQ21	A0A482WFA2	A0A482WQ21	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.918
A0A482WFA2	A0A482WRI4	A0A482WFA2	A0A482WRI4	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.854
A0A482WFA2	A0A482WSU1	A0A482WFA2	A0A482WSU1	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.854
A0A482WFA2	A0A482WXS7	A0A482WFA2	A0A482WXS7	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.877
A0A482WFA2	A0A482X1J8	A0A482WFA2	A0A482X1J8	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.855
A0A482WFA2	A0A482X968	A0A482WFA2	A0A482X968	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.897
A0A482WFA2	A0A482XIX8	A0A482WFA2	A0A482XIX8	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.897
A0A482WFA2	hsc70	A0A482WFA2	A0A109UU25	ANK_REP_REGION domain-containing protein.	Heat shock protein cognate 70; Belongs to the heat shock protein 70 family.	0.854
A0A482WHJ7	A0A482WFA2	A0A482WHJ7	A0A482WFA2	Uncharacterized protein; Belongs to the heat shock protein 70 family.	ANK_REP_REGION domain-containing protein.	0.897
A0A482WHJ7	A0A482WPY3	A0A482WHJ7	A0A482WPY3	Uncharacterized protein; Belongs to the heat shock protein 70 family.	J domain-containing protein.	0.834
A0A482WHJ7	A0A482WQ21	A0A482WHJ7	A0A482WQ21	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.896
A0A482WHJ7	A0A482WRI4	A0A482WHJ7	A0A482WRI4	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.605
A0A482WHJ7	A0A482WSU1	A0A482WHJ7	A0A482WSU1	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.606
A0A482WHJ7	A0A482WXS7	A0A482WHJ7	A0A482WXS7	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.744
A0A482WHJ7	hsc70	A0A482WHJ7	A0A109UU25	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock protein cognate 70; Belongs to the heat shock protein 70 family.	0.606
A0A482WPY3	A0A482WFA2	A0A482WPY3	A0A482WFA2	J domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.719
A0A482WPY3	A0A482WHJ7	A0A482WPY3	A0A482WHJ7	J domain-containing protein.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.834
A0A482WPY3	A0A482WQ21	A0A482WPY3	A0A482WQ21	J domain-containing protein.	Uncharacterized protein.	0.746

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Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.826

expected number of edges:

11

PPI enrichment p-value:

3.13e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006836

Neurotransmitter transport

7 of 137

2.03

3.96

8.35e-10

GO:0098700

Neurotransmitter loading into synaptic vesicle

4 of 10

2.92

3.92

6.00e-08

GO:0099504

Synaptic vesicle cycle

6 of 127

2.0

3.25

6.00e-08

GO:0001505

Regulation of neurotransmitter levels

5 of 178

1.77

2.1

1.79e-05

GO:0017156

Calcium-ion regulated exocytosis

3 of 42

2.18

1.57

0.0010

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015495

Gamma-aminobutyric acid:proton symporter activity

3 of 3

3.32

2.97

4.36e-06

GO:0015187

Glycine transmembrane transporter activity

3 of 6

3.02

2.77

9.14e-06

GO:0015294

Solute:cation symporter activity

4 of 132

1.8

1.79

0.00014

GO:0016413

O-acetyltransferase activity

2 of 12

2.54

1.35

0.0034

GO:0042910

Xenobiotic transmembrane transporter activity

2 of 25

2.22

1.1

0.0089

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043679

Axon terminus

5 of 56

2.27

3.78

2.09e-08

GO:0051286

Cell tip

3 of 3

3.32

3.61

2.89e-07

GO:0048786

Presynaptic active zone

5 of 70

2.18

3.6

3.02e-08

GO:0044292

Dendrite terminus

3 of 8

2.9

3.18

1.47e-06

GO:0098793

Presynapse

8 of 405

1.62

2.93

9.78e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23104

Mixed, incl. Norepinephrine Neurotransmitter Release Cycle, and Vesicle fusion to plasma membrane

8 of 65

2.41

6.74

5.33e-15

CL:23106

Norepinephrine Neurotransmitter Release Cycle, and Vesicle fusion to plasma membrane

5 of 58

2.26

3.74

2.36e-08

CL:23108

Mixed, incl. Vesicle fusion to plasma membrane, and Serotonin Neurotransmitter Release Cycle

3 of 32

2.29

1.96

0.00019

CL:23162

Mixed, incl. Acetate ester transmembrane transporter activity, and Cell tip

2 of 5

2.92

1.56

0.0015

CL:27951

Acyltransferase ChoActase/COT/CPT, and Glycerophosphodiester phosphodiesterase domain

2 of 12

2.54

1.21

0.0060

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112310

Neurotransmitter release cycle

8 of 112

2.18

5.63

1.15e-13

MAP-888590

GABA synthesis, release, reuptake and degradation

5 of 42

2.4

4.11

7.17e-09

MAP-264642

Acetylcholine Neurotransmitter Release Cycle

4 of 37

2.36

3.09

9.36e-07

MAP-112315

Transmission across Chemical Synapses

8 of 454

1.57

2.7

3.18e-09

MAP-112316

Neuronal System

8 of 696

1.38

2.05

4.59e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044292

Dendrite terminus

3 of 9

2.84

2.75

8.99e-06

GOCC:0098793

Presynapse

6 of 197

1.81

2.73

2.93e-07

GOCC:0030285

Integral component of synaptic vesicle membrane

3 of 14

2.65

2.53

2.08e-05

GOCC:0030658

Transport vesicle membrane

4 of 89

1.97

2.22

2.40e-05

GOCC:0045202

Synapse

7 of 545

1.43

1.93

1.00e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01490

Transmembrane amino acid transporter protein

3 of 15

2.62

2.07

0.00015

PF02318

FYVE-type zinc finger

2 of 12

2.54

0.91

0.0218

PF00755

Choline/Carnitine o-acyltransferase

2 of 12

2.54

0.91

0.0218

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013057

Amino acid transporter, transmembrane domain

3 of 17

2.57

1.73

0.00066

IPR004734

Multidrug resistance protein

2 of 4

3.02

1.08

0.0111

IPR039032

Rim-like

2 of 7

2.78

0.97

0.0177

IPR042231

Choline/Carnitine o-acyltransferase, domain 2

2 of 11

2.58

0.85

0.0288

IPR041282

FYVE-type zinc finger

2 of 12

2.54

0.85

0.0288

(more ...)

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