A0A482XAL9 protein (Laodelphax striatellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

A0A482XAL9

Uncharacterized protein. (709 aa)

Predicted Functional Partners:

A0A482WLK9

0.987

A0A482X5W0

0.987

A0A482X5Z6

0.987

A0A482WR75

0.982

A0A482XF72

0.982

A0A482WM48

0.979

A0A482XA58

0.959

A0A482XAP9

0.959

A0A482XLS6

0.959

A0A482WQJ3

0.958

Your Current Organism:

Laodelphax striatellus

NCBI taxonomy Id: 195883
Other names: L. striatellus, Laodelphax striatella, small brown planthopper

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A482WLK9	A0A482WM48	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.998
A0A482WLK9	A0A482WQJ3	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.997
A0A482WLK9	A0A482WR75	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.990
A0A482WLK9	A0A482X5W0	ANK_REP_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.999
A0A482WLK9	A0A482X5Z6	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.999
A0A482WLK9	A0A482XA58	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.991
A0A482WLK9	A0A482XAL9	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.987
A0A482WLK9	A0A482XAP9	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.991
A0A482WLK9	A0A482XF72	ANK_REP_REGION domain-containing protein.	Protein kinase domain-containing protein.	0.990
A0A482WLK9	A0A482XLS6	ANK_REP_REGION domain-containing protein.	Fibronectin type-III domain-containing protein.	0.991
A0A482WM48	A0A482WLK9	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.998
A0A482WM48	A0A482WQJ3	Uncharacterized protein.	Uncharacterized protein.	0.983
A0A482WM48	A0A482WR75	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.861
A0A482WM48	A0A482X5W0	Uncharacterized protein.	Protein kinase domain-containing protein.	0.998
A0A482WM48	A0A482X5Z6	Uncharacterized protein.	Uncharacterized protein.	0.998
A0A482WM48	A0A482XA58	Uncharacterized protein.	Uncharacterized protein.	0.843
A0A482WM48	A0A482XAL9	Uncharacterized protein.	Uncharacterized protein.	0.979
A0A482WM48	A0A482XAP9	Uncharacterized protein.	Uncharacterized protein.	0.843
A0A482WM48	A0A482XF72	Uncharacterized protein.	Protein kinase domain-containing protein.	0.861
A0A482WM48	A0A482XLS6	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.843

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.826

expected number of edges:

11

PPI enrichment p-value:

3.13e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006836

Neurotransmitter transport

7 of 137

2.03

3.96

8.35e-10

GO:0098700

Neurotransmitter loading into synaptic vesicle

4 of 10

2.92

3.92

6.00e-08

GO:0099504

Synaptic vesicle cycle

6 of 127

2.0

3.25

6.00e-08

GO:0001505

Regulation of neurotransmitter levels

5 of 178

1.77

2.1

1.79e-05

GO:0017156

Calcium-ion regulated exocytosis

3 of 42

2.18

1.57

0.0010

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015495

Gamma-aminobutyric acid:proton symporter activity

3 of 3

3.32

2.97

4.36e-06

GO:0015187

Glycine transmembrane transporter activity

3 of 6

3.02

2.77

9.14e-06

GO:0015294

Solute:cation symporter activity

4 of 132

1.8

1.79

0.00014

GO:0016413

O-acetyltransferase activity

2 of 12

2.54

1.35

0.0034

GO:0042910

Xenobiotic transmembrane transporter activity

2 of 25

2.22

1.1

0.0089

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043679

Axon terminus

5 of 56

2.27

3.78

2.09e-08

GO:0051286

Cell tip

3 of 3

3.32

3.61

2.89e-07

GO:0048786

Presynaptic active zone

5 of 70

2.18

3.6

3.02e-08

GO:0044292

Dendrite terminus

3 of 8

2.9

3.18

1.47e-06

GO:0098793

Presynapse

8 of 405

1.62

2.93

9.78e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23104

Mixed, incl. Norepinephrine Neurotransmitter Release Cycle, and Vesicle fusion to plasma membrane

8 of 65

2.41

6.74

5.33e-15

CL:23106

Norepinephrine Neurotransmitter Release Cycle, and Vesicle fusion to plasma membrane

5 of 58

2.26

3.74

2.36e-08

CL:23108

Mixed, incl. Vesicle fusion to plasma membrane, and Serotonin Neurotransmitter Release Cycle

3 of 32

2.29

1.96

0.00019

CL:23162

Mixed, incl. Acetate ester transmembrane transporter activity, and Cell tip

2 of 5

2.92

1.56

0.0015

CL:27951

Acyltransferase ChoActase/COT/CPT, and Glycerophosphodiester phosphodiesterase domain

2 of 12

2.54

1.21

0.0060

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112310

Neurotransmitter release cycle

8 of 112

2.18

5.63

1.15e-13

MAP-888590

GABA synthesis, release, reuptake and degradation

5 of 42

2.4

4.11

7.17e-09

MAP-264642

Acetylcholine Neurotransmitter Release Cycle

4 of 37

2.36

3.09

9.36e-07

MAP-112315

Transmission across Chemical Synapses

8 of 454

1.57

2.7

3.18e-09

MAP-112316

Neuronal System

8 of 696

1.38

2.05

4.59e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044292

Dendrite terminus

3 of 9

2.84

2.75

8.99e-06

GOCC:0098793

Presynapse

6 of 197

1.81

2.73

2.93e-07

GOCC:0030285

Integral component of synaptic vesicle membrane

3 of 14

2.65

2.53

2.08e-05

GOCC:0030658

Transport vesicle membrane

4 of 89

1.97

2.22

2.40e-05

GOCC:0045202

Synapse

7 of 545

1.43

1.93

1.00e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01490

Transmembrane amino acid transporter protein

3 of 15

2.62

2.07

0.00015

PF02318

FYVE-type zinc finger

2 of 12

2.54

0.91

0.0218

PF00755

Choline/Carnitine o-acyltransferase

2 of 12

2.54

0.91

0.0218

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013057

Amino acid transporter, transmembrane domain

3 of 17

2.57

1.73

0.00066

IPR004734

Multidrug resistance protein

2 of 4

3.02

1.08

0.0111

IPR039032

Rim-like

2 of 7

2.78

0.97

0.0177

IPR042231

Choline/Carnitine o-acyltransferase, domain 2

2 of 11

2.58

0.85

0.0288

IPR041282

FYVE-type zinc finger

2 of 12

2.54

0.85

0.0288

(more ...)

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