SAMN03159343_4145 protein (Klenkia marina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SAMN03159343_4145

CopC domain-containing protein. (218 aa)

Predicted Functional Partners:

SAMN03159343_4144

0.906

SAMN03159343_1599

0.874

SAMN03159343_3791

0.828

SAMN03159343_0160

0.819

SAMN03159343_2276

0.761

SAMN03159343_1006

0.731

SAMN03159343_0628

0.680

SAMN03159343_4146

0.526

Your Current Organism:

Klenkia marina

NCBI taxonomy Id: 1960309
Other names: Actinobacteria bacterium DSM 45722, CCTCC AB 2012057, CCTCC:AB:2012057, DSM 45722, Geodermatophilus sp. YIM M1316, K. marina, Klenkia marina Montero-Calasanz et al. 2018, YIM M13156

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
SAMN03159343_0160	SAMN03159343_4144	Uncharacterized protein YcnI.	Putative copper resistance protein D.	0.864
SAMN03159343_0160	SAMN03159343_4145	Uncharacterized protein YcnI.	CopC domain-containing protein.	0.819
SAMN03159343_0628	SAMN03159343_1006	Uncharacterized protein.	Uncharacterized iron-regulated membrane protein.	0.409
SAMN03159343_0628	SAMN03159343_3791	Uncharacterized protein.	Deferrochelatase/peroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family.	0.795
SAMN03159343_0628	SAMN03159343_4144	Uncharacterized protein.	Putative copper resistance protein D.	0.408
SAMN03159343_0628	SAMN03159343_4145	Uncharacterized protein.	CopC domain-containing protein.	0.680
SAMN03159343_0628	SAMN03159343_4146	Uncharacterized protein.	Cytochrome C and Quinol oxidase polypeptide I.	0.877
SAMN03159343_1006	SAMN03159343_0628	Uncharacterized iron-regulated membrane protein.	Uncharacterized protein.	0.409
SAMN03159343_1006	SAMN03159343_3791	Uncharacterized iron-regulated membrane protein.	Deferrochelatase/peroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family.	0.683
SAMN03159343_1006	SAMN03159343_4145	Uncharacterized iron-regulated membrane protein.	CopC domain-containing protein.	0.731
SAMN03159343_1599	SAMN03159343_4145	NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase.	CopC domain-containing protein.	0.874
SAMN03159343_2276	SAMN03159343_4145	Integral membrane protein.	CopC domain-containing protein.	0.761
SAMN03159343_3791	SAMN03159343_0628	Deferrochelatase/peroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family.	Uncharacterized protein.	0.795
SAMN03159343_3791	SAMN03159343_1006	Deferrochelatase/peroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family.	Uncharacterized iron-regulated membrane protein.	0.683
SAMN03159343_3791	SAMN03159343_4145	Deferrochelatase/peroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family.	CopC domain-containing protein.	0.828
SAMN03159343_4144	SAMN03159343_0160	Putative copper resistance protein D.	Uncharacterized protein YcnI.	0.864
SAMN03159343_4144	SAMN03159343_0628	Putative copper resistance protein D.	Uncharacterized protein.	0.408
SAMN03159343_4144	SAMN03159343_4145	Putative copper resistance protein D.	CopC domain-containing protein.	0.906
SAMN03159343_4144	SAMN03159343_4146	Putative copper resistance protein D.	Cytochrome C and Quinol oxidase polypeptide I.	0.549
SAMN03159343_4145	SAMN03159343_0160	CopC domain-containing protein.	Uncharacterized protein YcnI.	0.819

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

48

PPI enrichment p-value:

0.0411

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

7 of 19

1.93

3.65

1.72e-09

GO:0009408

Response to heat

5 of 9

2.11

3.0

5.64e-07

GO:0042026

Protein refolding

2 of 3

2.18

0.82

0.0305

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005515

Protein binding

6 of 29

1.68

2.35

1.11e-06

GO:0051082

Unfolded protein binding

4 of 10

1.96

2.27

1.77e-05

GO:0016887

ATP hydrolysis activity

4 of 41

1.35

1.16

0.00099

GO:0031072

Heat shock protein binding

2 of 4

2.06

1.16

0.0063

GO:0030554

Adenyl nucleotide binding

10 of 294

0.89

0.94

1.51e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 875

0.46

0.38

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:398

Protein folding, and ATP-dependent peptidase activity

8 of 22

1.92

4.26

1.29e-11

CL:400

Stress response, and Protein folding chaperone

7 of 15

2.03

4.25

1.19e-10

CL:403

Stress response, and Protein folding chaperone

4 of 8

2.06

2.33

1.78e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

5 of 7

2.21

3.47

7.84e-08

KW-0143

Chaperone

5 of 13

1.95

2.88

4.19e-07

KW-0677

Repeat

3 of 10

1.84

1.45

0.0011

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02861

Clp amino terminal domain, pathogenicity island component

2 of 2

2.36

0.76

0.0400

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003959

ATPase, AAA-type, core

3 of 7

1.99

1.2

0.0049

IPR041546

ClpA/ClpB, AAA lid domain

2 of 2

2.36

0.79

0.0352

IPR036869

Chaperone J-domain superfamily

2 of 3

2.18

0.79

0.0352

IPR036628

Clp, N-terminal domain superfamily

2 of 2

2.36

0.79

0.0352

IPR028299

ClpA/B, conserved site 2

2 of 2

2.36

0.79

0.0352

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01086

C-terminal, D2-small domain, of ClpB protein

2 of 4

2.06

0.87

0.0232

SM00271

DnaJ molecular chaperone homology domain

2 of 4

2.06

0.87

0.0232

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Textmining

Cooccurrence

Databases

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About