PHISP_07387 protein (Phialosimplex sp. HF37)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

PHISP_07387

L-ascorbic acid binding protein. (631 aa)

Predicted Functional Partners:

PHISP_00656

0.994

PHISP_08497

0.993

PHISP_07563

0.903

PHISP_04437

0.786

PHISP_08637

0.784

PHISP_07531

0.625

PHISP_01260

0.604

PHISP_05553

0.571

PHISP_02783

0.564

PHISP_07098

0.563

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHISP_00656	PHISP_02783	A0A3M2TF95	A0A3M2T9B3	Elongation factor 3.	Uncharacterized protein.	0.747
PHISP_00656	PHISP_05553	A0A3M2TF95	A0A3M2T163	Elongation factor 3.	Ribosome biogenesis protein tsr1.	0.711
PHISP_00656	PHISP_07098	A0A3M2TF95	A0A3M2SX73	Elongation factor 3.	40s ribosomal protein s23; Belongs to the universal ribosomal protein uS12 family.	0.994
PHISP_00656	PHISP_07387	A0A3M2TF95	A0A3M2SW17	Elongation factor 3.	L-ascorbic acid binding protein.	0.994
PHISP_00656	PHISP_07563	A0A3M2TF95	A0A3M2SVZ8	Elongation factor 3.	Uncharacterized protein.	0.997
PHISP_00656	PHISP_08497	A0A3M2TF95	A0A3M2SST9	Elongation factor 3.	Elongation factor 3.	0.996
PHISP_01260	PHISP_07387	A0A3M2TDG8	A0A3M2SW17	Coproporphyrinogen III oxidase.	L-ascorbic acid binding protein.	0.604
PHISP_02783	PHISP_00656	A0A3M2T9B3	A0A3M2TF95	Uncharacterized protein.	Elongation factor 3.	0.747
PHISP_02783	PHISP_05553	A0A3M2T9B3	A0A3M2T163	Uncharacterized protein.	Ribosome biogenesis protein tsr1.	0.403
PHISP_02783	PHISP_07098	A0A3M2T9B3	A0A3M2SX73	Uncharacterized protein.	40s ribosomal protein s23; Belongs to the universal ribosomal protein uS12 family.	0.593
PHISP_02783	PHISP_07387	A0A3M2T9B3	A0A3M2SW17	Uncharacterized protein.	L-ascorbic acid binding protein.	0.564
PHISP_02783	PHISP_07563	A0A3M2T9B3	A0A3M2SVZ8	Uncharacterized protein.	Uncharacterized protein.	0.806
PHISP_02783	PHISP_08497	A0A3M2T9B3	A0A3M2SST9	Uncharacterized protein.	Elongation factor 3.	0.812
PHISP_04437	PHISP_07098	A0A3M2T4G0	A0A3M2SX73	Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	40s ribosomal protein s23; Belongs to the universal ribosomal protein uS12 family.	0.964
PHISP_04437	PHISP_07387	A0A3M2T4G0	A0A3M2SW17	Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	L-ascorbic acid binding protein.	0.786
PHISP_05553	PHISP_00656	A0A3M2T163	A0A3M2TF95	Ribosome biogenesis protein tsr1.	Elongation factor 3.	0.711
PHISP_05553	PHISP_02783	A0A3M2T163	A0A3M2T9B3	Ribosome biogenesis protein tsr1.	Uncharacterized protein.	0.403
PHISP_05553	PHISP_07098	A0A3M2T163	A0A3M2SX73	Ribosome biogenesis protein tsr1.	40s ribosomal protein s23; Belongs to the universal ribosomal protein uS12 family.	0.928
PHISP_05553	PHISP_07387	A0A3M2T163	A0A3M2SW17	Ribosome biogenesis protein tsr1.	L-ascorbic acid binding protein.	0.571
PHISP_05553	PHISP_07563	A0A3M2T163	A0A3M2SVZ8	Ribosome biogenesis protein tsr1.	Uncharacterized protein.	0.903

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.881

expected number of edges:

15

PPI enrichment p-value:

6.79e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051276

Chromosome organization

5 of 26

1.86

2.37

5.40e-06

GO:0071103

DNA conformation change

4 of 17

1.95

2.05

5.67e-05

GO:0006281

DNA repair

5 of 51

1.57

1.72

5.67e-05

GO:0006259

DNA metabolic process

8 of 178

1.23

1.49

3.02e-06

GO:0006260

DNA replication

3 of 36

1.5

0.95

0.0083

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008094

ATP-dependent activity, acting on DNA

6 of 21

2.03

3.7

4.95e-09

GO:0140097

Catalytic activity, acting on DNA

10 of 107

1.55

3.13

1.83e-12

GO:0003678

DNA helicase activity

3 of 8

2.15

1.85

0.00025

GO:0003887

DNA-directed DNA polymerase activity

3 of 11

2.01

1.67

0.00049

GO:0140664

ATP-dependent DNA damage sensor activity

2 of 4

2.27

1.21

0.0057

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009360

DNA polymerase III complex

2 of 5

2.18

0.95

0.0170

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:599

Mixed, incl. Mismatched DNA binding, and DNA helicase activity

6 of 7

2.51

5.44

1.54e-11

CL:595

DNA repair, and Primosome

8 of 25

2.08

5.21

3.03e-13

CL:596

DNA repair, and DNA helicase activity

7 of 18

2.16

5.0

6.03e-12

CL:593

DNA repair, and DNA-directed DNA polymerase activity

9 of 41

1.92

4.75

1.32e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03430

Mismatch repair

6 of 27

1.92

3.41

9.30e-09

map03440

Homologous recombination

5 of 30

1.8

2.56

9.32e-07

map03420

Nucleotide excision repair

3 of 13

1.94

1.72

0.00033

map03030

DNA replication

3 of 35

1.51

1.09

0.0037

map03410

Base excision repair

2 of 22

1.53

0.67

0.0449

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033202

DNA helicase complex

3 of 5

2.35

1.91

0.00025

GOCC:0044815

DNA packaging complex

3 of 11

2.01

1.65

0.00053

GOCC:0009360

DNA polymerase III complex

2 of 6

2.1

0.98

0.0142

GOCC:1902494

Catalytic complex

5 of 245

0.88

0.58

0.0142

GOCC:0005622

Intracellular

10 of 1593

0.37

0.28

0.0241

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

3 of 12

1.97

1.45

0.0014

KW-0234

DNA repair

3 of 28

1.6

1.1

0.0044

KW-0548

Nucleotidyltransferase

3 of 32

1.55

1.08

0.0044

KW-0239

DNA-directed DNA polymerase

2 of 8

1.97

1.04

0.0104

KW-0238

DNA-binding

6 of 209

1.03

0.85

0.0014

(more ...)

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